Sepsis clinical trials at UCSF

6 in progress, 5 open to eligible people

Showing trials for

  • Gram-Negative Bloodstream Infection Oral Antibiotic Therapy Trial

    open to eligible people ages 18 years and up

    The Gram-negative bloodstream infection Oral Antibiotic Therapy trial (The GOAT Trial) is a multi-center, randomized clinical trial that hypothesizes that early transition to oral antibiotic therapy for the treatment of Gram-Negative BloodStream Infection (GN-BSI) is as effective but safer than remaining on intravenous (IV) antibiotic therapy for the duration of treatment.

    San Francisco, California and other locations

  • TIN816 in Sepsis-associated Acute Kidney Injury (SA-AKI)

    open to eligible people ages 18-85

    The purpose of this Ph2b study is to characterize the dose-response relationship and to evaluate the safety and efficacy of three different single doses of TIN816 in hospitalized adult participants in an intensive care setting with a diagnosis of sepsis-associated acute kidney injury (SA-AKI).

    San Francisco, California and other locations

  • Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis

    open to eligible people ages 2 months to 17 years

    The objectives of this multicenter pragmatic clinical trial are to compare the effectiveness and relative safety of balanced fluid resuscitation versus 0.9% "normal" saline in children with septic shock, including whether balanced fluid resuscitation can reduce progression of kidney injury.

    San Francisco, California and other locations

  • Targeted Reversal of Inflammation in Pediatric Sepsis-induced MODS

    open to eligible people ages up to 17 years

    The TRIPS study is a prospective, multi-center, double-blind, adaptively randomized, placebo-controlled clinical trial of the drug anakinra for reversal of moderate to severe hyperinflammation in children with sepsis-induced multiple organ dysfunction syndrome (MODS).

    Oakland, California and other locations

  • Role of Transposable Elements in Septic Immune Aging

    open to eligible people ages 18 years and up

    The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1. Do transposable elements prematurely age the immune systems of patients with sepsis? 2. Do transposable elements correlate with increased mortality in patients with sepsis in the ICU? 3. Do transposable elements correlate with increased amount of secondary infections in patients with sepsis in the ICU? Participants will have blood drawn from them but will not be subjected to additional interventions.

    San Francisco, California

  • APS Phenotyping Study

    Sorry, not currently recruiting here

    The goal of the observational APS phenotyping study is to better understand risk factors, potential biomarkers, length and severity of illness, and recovery for adults with ARDS, pneumonia, and/ or sepsis. This study will also generate a biobank of specimens collected from these patients that will be available to investigators for future studies of ARDS, sepsis, and/or pneumonia.

    San Francisco, California and other locations

Our lead scientists for Sepsis research studies include .

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