Treatment Adherence clinical trials at UCSF

2 in progress, 1 open to eligible people

Adherence to treatment means taking medications exactly as prescribed. At UCSF, researchers study how not using eye drops after cataract surgery might affect patients at a county hospital. They are seeing if this approach works better for people who may struggle to follow complex regimens.

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  • Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

    open to eligible people ages 18 years and up

    The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the development of postoperative complications. The investigators propose to replace this complex regimen with a single administration of intraocular antibiotic and subconjunctival steroid at the time of surgery. This pilot study will obtain the preliminary data required to eventually fully evaluate this innovation in postoperative care in a safety-net population with respect to postoperative outcomes, patient compliance, and patient and caregiver satisfaction.

    San Francisco, California

  • PrEP Affect Regulation Treatment Innovation

    Sorry, in progress, not accepting new patients

    This multi-site randomized controlled trial enrolling sexual minority men who use stimulants and are currently taking pre-exposure prophylaxis (PrEP). This randomized controlled trial will test the efficacy of a PrEP Affect Regulation Treatment Innovation (PARTI) condition comprised of a 5-session positive affect intervention delivered during smartphone-based Contingency Management (CM) for directly observed PrEP doses (PARTI+CM) compared to an attention-control condition delivered during CM. The primary outcome is HIV acquisition risk measured using a combination of tenofovir-diphosphate levels in dried blood spots that are indicative of sub-optimal adherence to PrEP and recent condomless anal sex.

    San Francisco, California and other locations

Our lead scientists for Treatment Adherence research studies include .

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