Treatment Adherence clinical trials at UCSF
4 in progress, 2 open to eligible people
Treatment adherence means following a doctor's advice about taking medicine or following a health plan. UCSF is studying how well patients stick to their eye drop routine after cataract surgery and how sexual minority men use PrEP while using stimulants. These studies help improve patient care.
Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population
open to eligible people ages 18 years and up
The current postoperative cataract surgery eye drop regimen used at Zuckerberg San Francisco General Hospital (ZSFG) is a significant burden for its patient population, contributing to high rates of non-adherence and the development of postoperative complications. The investigators propose to replace this complex regimen with a single administration of intraocular antibiotic and subconjunctival steroid at the time of surgery. This pilot study will obtain the preliminary data required to eventually fully evaluate this innovation in postoperative care in a safety-net population with respect to postoperative outcomes, patient compliance, and patient and caregiver satisfaction.
San Francisco, California
PrEP Affect Regulation Treatment Innovation
open to eligible males ages 18 years and up
This multi-site randomized controlled trial enrolling sexual minority men who use stimulants and are currently taking pre-exposure prophylaxis (PrEP). This randomized controlled trial will test the efficacy of a PrEP Affect Regulation Treatment Innovation (PARTI) condition comprised of a 5-session positive affect intervention delivered during smartphone-based Contingency Management (CM) for directly observed PrEP doses (PARTI+CM) compared to an attention-control condition delivered during CM. The primary outcome is HIV acquisition risk measured using a combination of tenofovir-diphosphate levels in dried blood spots that are indicative of sub-optimal adherence to PrEP and recent condomless anal sex.
San Francisco, California and other locations
Improving Medication Adherence in Adolescents Who Had a Liver Transplant
Sorry, in progress, not accepting new patients
The study's aim is to test a tailored telemetric intervention to reduce rejection incidence by improving medication adherence in a group of adolescent liver transplant recipients identified as nonadherent by a marker (the Medication Level Variability Index, MLVI).
San Francisco, California and other locations
Medication Adherence With Telehealthcare Medication Therapy Management
Sorry, in progress, not accepting new patients
Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of Adolescents and Young Adults (AYA) with uncontrolled asthma who have poor adherence with prescribed Inhaled corticosteroid (ICS) therapy.
San Francisco, California and other locations
Our lead scientists for Treatment Adherence research studies include Sriranjani Padmanabhan Mallory Johnson, PhD.
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