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for females ages 50 years and up (full criteria)
study started
estimated completion:



A recent National Health Interview Survey reported that breathing exercises were the second most common complementary and alternative medicine practice in the United States, following only the use of "natural products." With such widespread interest in breathing exercises, alone or as a component of practices such as meditation, a need exists for research that examines not only its efficacy, but also investigates potential mechanisms of action. Indeed, a recent National Center for Complementary and Alternative Medicine (NCCAM) Meditation Workshop recommended research to clarify biological pathways by which meditation practices, including breathing exercises, can impact health. To explore mechanisms underlying the health effects of breathing exercises, new translational tools are needed that can measure breathing patterns in both the clinic and natural environment. The primary objective of the present proposal is the application of a new technology to the investigation of pathways by which breathing exercises can affect health. For this project, the health-related outcome measure to be studied is a major cardiovascular risk factor, blood pressure.

Official Title

Project Inspire: A New Translational Tool for Studying the Role of Breathing in Meditation


Hypertension Blood pressure Breathing PetCO2 Stress Respiratory Aspiration


You can join if…

Open to females ages 50 years and up

  • Mean 24-hr SBP: 130-139 mmHg
  • Female
  • > 50 years of age
  • Post menopausal, defined as greater than or equal to one year without a menstrual cycle.
  • Body Mass Index (BMI): 19-31
  • English speaking (Patients not able to read and speak English will be excluded as the behavioral group interventions are conducted in English)
  • Has a personal physician

You CAN'T join if...

(Individuals will be filtered in the KP OSCA database according to the following ICD-9 codes):


  • 491.X chronic Bronchitis incl COPD
  • 492.X emphysema
  • 493.X asthma
  • 494-496; 500-519: all kinds of chronic pulmonary conditions


  • 404.9 chronic ischemic heart disease
  • 425.X cardiomyopathies
  • 428.X heart failure
  • 430-438 cerebrovascular diseases


  • 582-583 chronic glomerulonephritis
  • 584-588 renal failure


  • 571.X chronic liver disease and cirrhosis Smoker: 305.1


  • 290-299 dementia/schizophrenia/ psychoses…
  • 303, 304 alcohol or drug dependence
  • 317-319 mental retardation


  • All blood pressure medications
  • All tranquilizers, benzodiazepins if prescribed regularly, e.g. every month
  • All narcotics if prescribed regularly, e.g. every month


  • Plan to relocate residence outside recruitment area during the intervention or follow- period


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Lead Scientist
Margaret A Chesney
Study Type
Last Updated
October 2016