for people ages 18-40 (full criteria)
Healthy Volunteers
healthy people welcome
at San Francisco, California
study started
completion around
Principal Investigator
by Elaine Ku, MD MAS
Headshot of Elaine Ku
Elaine Ku



This is a pilot randomized controlled trial which will test the effect of 3 different anti-hypertensive agents and 3 different strategies of engaging young adults in home blood pressure monitoring on blood pressure control, with secondary outcomes focused on quality of life and adverse events.


Hypertension, Losartan, Amlodipine, Chlorthalidone, Antihypertensive Agents, Anti-hypertensive agent: amlodipine, Anti-hypertensive agent: Chlorthalidone, Anti-hypertensive agent: Losartan, Home BP monitoring with cuffed device, Home BP monitoring with cuffed device + BP patch, Home BP monitoring with cuffed device + BP watch


You can join if…

Open to people ages 18-40

  • 18-40 years of age
  • Diagnosis of hypertension or receiving anti-hypertensive therapy OR Has clinical BP readings >130/80 mmHg that would meet the definition of hypertension and have home BP readings >=125/80 mmHg

You CAN'T join if...

  • are or are planning to become pregnant, due to inability to take multiple classes of anti- hypertensive agents
  • are marginally housed, due to concerns regarding routine follow-up
  • are actively participating in a different interventional trial that may affect blood pressure
  • are unwilling to consent to participate
  • institutionalized individuals or prisoners
  • are actively abusing illicit drugs or alcohol
  • have a history of poor or doubtful compliance (e.g., frequently missed appointments)
  • have cognitive impairment prohibiting participation in the study
  • History of allergy to any of the randomized medications
  • Serum potassium >5.5 meq/L at the screening visit
  • BP > 160/100 mmHg in clinic (stage II hypertension), regardless of whether patient is on therapy
  • eGFR < 30 mL/min/1.73 m2


  • UCSF accepting new patients
    San Francisco California 94143 United States

Lead Scientist at UCSF

  • Elaine Ku, MD MAS
    The global context of my research program focuses on understanding differences in the epidemiology, clinical management, and outcomes of children versus adults with kidney disease and the conduct of clinical trials to test interventions (such as blood pressure control) that will improve survival of patients with kidney disease.


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Phase 2 High Blood Pressure Research Study
Study Type
Expecting 120 study participants
Last Updated