for people ages 45-90 (full criteria)
at San Francisco, California and other locations
study started
completion around
Principal Investigator
by Adam Boxer, MD, PhD
Headshot of Adam Boxer
Adam Boxer



The purpose of this study is to evaluate several different tests, including brain imaging, eye movement testing, body fluid samples, measurements of memory and other thinking abilities, and measures of functional independence in the hope that this information can be used to guide diagnosis and treatment of PSP and CBD in the future. Recent advances in our understanding of the biological causes of these diseases offer hope for new treatments. As such treatments are developed, sensitive and specific biological measurements (biomarkers) will be needed to provide precise and direct measures of the state of the brain, which will improve the statistical power of clinical trials. Brain imaging with Magnetic Resonance Imaging (MRI) has previously been used to measure disease-related changes in the brain. The goal of this study is to identify the best methods of analysis (including eye movements, imaging, and behavioral measures) for tracking PSP and CBD over time. In addition, certain biomarkers in the blood and cerebrospinal fluid might also be useful for following these diseases over time. This study will examine the value of blood and CSF biomarkers relative to brain imaging and functional measures.

Official Title

Observational Longitudinal Study of Magnetic Resonance Imaging, Specimen Biomarkers, and Clinical Progression in Progressive Supranuclear Palsy and Corticobasal Degeneration


Progressive Supranuclear Palsy, Corticobasal Degeneration, Biomarker, Neuroimaging, MRI, Tau, Oculomotor


You can join if…

Open to people ages 45-90

You CAN'T join if...

  • Significant neurological disease other than PSP or CBD
  • Presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin or body


  • UCSF
    San Francisco California 94158 United States
  • John Hopkins University
    Baltimore Maryland 21218 United States

Lead Scientist at UCSF

  • Adam Boxer, MD, PhD
    Adam L. Boxer, MD, PhD is the Endowed Professor in Memory and Aging in the Department of Neurology, Weill Institute of Neuroscience, University of California, San Francisco (UCSF). He received his MD and PhD from the New York University Medical Center Medical Scientist Training Program, completed a Neurology Residency at Stanford and a Neurobehavior Fellowship at UCSF.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 110 study participants
Last Updated