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for people ages 18–65 (full criteria)
at San Francisco, California
study started
estimated completion:



The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).


The investigators will test whether Acthar gel's anti-inflammatory properties will modulate immune cells and lead to decreases in blood biomarkers and improvements in clinical parameters. Specific Aim 1 will examine the levels of the predictive biomarker, chemokine ligand 9 (CXCL9), and related transcripts, and determine whether they decrease in participants over time while taking Acthar. Specific Aim 2 will test whether the biologic changes measured in blood correlate to clinical markers, including lung function and symptom scores. Since the investigators have found that CXCL9 predicts clinical course, they hypothesize that CXCL9 transcript levels in the blood will decrease over time in pulmonary sarcoidosis participants whose clinical outcome measures improve with Acthar.


Sarcoidosis Acthar CXCL9 chemokine ligand 9 Adrenocorticotropic Hormone


You can join if…

Open to people ages 18–65

  • Biopsy-proven diagnosis of sarcoidosis with demonstrated pulmonary involvement
  • Refractoriness to or intolerance of immunosuppressive agents like prednisone or methotrexate

You CAN'T join if...

  • Smoking
  • Cancer
  • Chronic infections (e.g. tuberculosis, viral, fungal, bacterial)
  • Inflammatory conditions
  • Coexisting lung disease
  • Congestive heart failure
  • Uncontrolled hypertension
  • Recent surgery
  • Active peptic ulcers
  • Osteoporosis


  • University of California, San Francisco not yet accepting patients
    San Francisco, California, 94143, United States


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Homepage for the Sarcoidosis Research Program at the University of California, San Francisco
Phase 4
Lead Scientist
Laura Koth
Study Type
Last Updated
October 2016
I’m interested in this study!