at San Francisco, California and other locations
study started
estimated completion



Multi-center, prospective, observational cohort study of patients undergoing total pancreatectomy with islet autotransplantation (TPIAT)

Official Title

Advancing Treatment for Pancreatitis: A Prospective Observational Study of TPIAT (POST)


Patients who are undergoing TPIAT at one of the participating center are invited to participate in this observational study, with 450 participants anticipated. The aims of the study are:

Aim 1: To determine (1a) whether patient and disease characteristics are associated with favorable pain and health-related quality-of-life outcomes (HRQOL) after TPIAT; (1b) the optimal timing of the TPIAT intervention to resolve pain and improve HRQOL; and (1c) in a subset of patients, the impact of central sensitization on pain resolution.

Aim 2: To determine (2a) whether patient and disease characteristics are associated with favorable glycemic outcomes from the IAT procedure; and (2b) the optimal timing of TPIAT to obtain post-surgical insulin independence.

Aim 3: To determine the cost-effectiveness of TPIAT.


Pancreatitis, Chronic Pancreatectomy; Hyperglycemia Pancreatitis pediatric total pancreatectomy acute pancreatitis chronic pancreatitis islet transplant islet autotransplant Hyperglycemia TPIAT


You can join if…

  1. Any patient with chronic or recurrent acute pancreatitis undergoing total or completion pancreatectomy with islet autotransplantation at a participating center.

You CAN'T join if...

  1. Partial pancreatectomy
  2. TPIAT performed for a diagnosis other than chronic or recurrent acute pancreatitis (for example benign or malignant pancreatic tumor)


  • University of California, San Francisco accepting new patients
    San Francisco California 94143 United States
  • Baylor University Medical Center accepting new patients
    Dallas Texas 75246 United States


accepting new patients
Start Date
Completion Date
University of Minnesota
Study Type
Last Updated