for people ages 40 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Peter Ljubenkov



The purpose of this study is to assess the long-term safety and efficacy of ABBV-8E12 in subjects with progressive supranuclear palsy (PSP). In a subset of participants at participating sites, participants will be assigned digital sensor BioStamp to assess body position and gait.


Progressive Supranuclear Palsy (PSP) tauopathy Steele-Richardson-Olszewski Syndrome PSP Supranuclear Palsy, Progressive ABBV-8E12


You can join if…

Open to people ages 40 years and up

  • Subject completed the 52-week treatment period in Study M15-562 (NCT02985879).
  • In the opinion of the investigator, the subject was compliant during participation in Study M15-562 (NCT02985879).
  • Subject has an identified, reliable, study partner (e.g., caregiver, family member, social worker, or friend).

You CAN'T join if...

  • Subjects who weigh less than 44 kg (97 lbs) at the time of study entry.
  • Any contraindication or inability to tolerate brain magnetic resonance imaging (MRI).
  • Subject has any significant change in his/her medical condition that could interfere with the subject's participation in the study, could place the subject at increased risk, or could confound interpretation of study results.
  • More than 8 weeks have elapsed since the subject received his/her last dose of study drug in Study M15-562 (NCT02985879).
  • Subject is considered by the investigator, for any reason, to be an unsuitable candidate to receive ABBV-8E12 or the subject is considered by the investigator to be unable or unlikely to comply with the dosing schedule or study evaluations.


  • Univ California, San Francisco /ID# 165553
    San Francisco California 94143-2204 United States
  • Cedars-Sinai Medical Center /ID# 165567
    Beverly Hills California 90211 United States

Lead Scientist

  • Peter Ljubenkov
    Assistant Professor, Neurology. Authored (or co-authored) 9 research publications


in progress, not accepting new patients
Start Date
Completion Date
Phase 2
Study Type
Last Updated