Summary

for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion:
Tina Bhutani

Description

Summary

This is a three-arm, open-label study, which will examine the effect of Goeckerman therapy (combination of phototherapy and topical crude coal tar), crude coal tar alone, and phototherapy alone on the immunologic and genetic environment within psoriatic lesions.

Details

This is a three-arm, open-label study, which will examine the effect of Goeckerman therapy (combination of phototherapy and topical crude coal tar), crude coal tar alone, and phototherapy alone on the immunologic and genetic environment within psoriatic lesions. Fifteen subjects with moderate to severe psoriasis will be enrolled. The Goeckerman arm will receive daily treatments with coal tar combined with phototherapy for 5 days a week for 6 weeks. The coal tar arm will receive daily treatments with coal tar for 5 days a week for 6 weeks. The phototherapy arm will receive NB-UVB three times per week. Biopsy samples will be collected and undergo molecular profiling to evaluate Goeckerman therapy and help elucidate its mechanism of action.

Keywords

Psoriasis Vulgaris Psoriasis goeckerman phototherapy Coal Tar Goeckerman Therapy Crude Coal Tar Only Phototherapy Only

Eligibility

You can join if…

Open to people ages 18 years and up

  1. Male or female ≥ 18 years of age at enrollment.
  2. Documentation of predominately moderate to severe plaque psoriasis for at least 6 months prior to enrollment.
  3. Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
  4. Subject is considered a candidate for phototherapy or systemic therapy
  5. Body Surface Area (BSA) ≥ 5%.
  6. Physical exam within clinically acceptable limits.

You CAN'T join if...

  1. Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.
  2. Subject has predominantly non-plaque form of psoriasis.
  3. Subject has drug-induced psoriasis.
  4. Subject with current, or a history of, severe psoriatic arthritis well controlled on current therapy.
  5. Patient has absolute or relative contraindication to phototherapy, including photosensitizing disorders.
  6. Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
  7. Known HIV positive status.
  8. Known allergy to lidocaine, other local anesthetics, or any component of local anesthetic agents.

Location

  • UCSF Psoriasis and Skin Treatment Center accepting new patients
    San Francisco California 94118 United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT03662685
Phase
Phase 4
Lead Scientist
Tina Bhutani
Study Type
Interventional
Last Updated
September 5, 2018