for people ages 18 years and up (full criteria)
Healthy Volunteers
healthy people welcome
at San Francisco, California
study started
estimated completion
Principal Investigator
by Tina Bhutani, MD, MAS
Photo of Tina Bhutani
Tina Bhutani



Getting enough sleep is important for maximizing health and well-being. When it comes to health, sleep is as vital as regular exercise and eating a balanced diet. Not getting enough sleep can lead to health problems like heart attacks, diabetes, and even cancer. Since people with psoriasis have these same health problems, getting better sleep may help to keep them happier and healthier. This study will look at how people with psoriasis sleep and if their sleep is different than people without psoriasis.


A growing body of literature has revealed that patients with psoriasis are more likely to report sleep disturbance when compared to the general population. The cross-sectional study presented here will allow us to objectively and rigorously measure sleep architecture in psoriasis patients and compare it to healthy controls, If sleep dysfunction is confirmed in this population, then clinical interventions such as screening for sleep disturbance or promoting sleep hygiene could lead to meaningful improvements in patients' health, longevity, and overall quality of life.


Psoriasis Vulgaris Psoriasis Polysomnography (PSG) Moderate to Severe Psoriasis


You can join if…

Open to people ages 18 years and up

  1. Patients with a diagnosis of moderate to severe plaque type psoriasis confirmed by the principal investigator. Moderate to severe psoriasis will be defined as affected BSA ≥3%. Healthy controls will be age, sex, and BMI matched (see below) subjects with no prior or current history of psoriasis.
  2. Are at least 18 years of age
  3. Psoriasis has been stable over the last 3 months
  4. Psoriasis is either untreated or treated only with topicals at the current time (see

You CAN'T join if...

for washout times)

  1. Subjectively reported poor sleep quality using the Pittsburg Sleep Quality Index (PSQI) (defined as a global score >5)
  2. Fluent in English
  3. Demonstrate understanding of the study and willingness to participate as evidenced by voluntary informed consent

Exclusion Criteria:

  1. Patients with guttate, erythrodermic, or pustular psoriasis subtypes
  2. Having a previous diagnosis of obstructive sleep apnea (OSA) or another medically defined sleep disorder or fall into the intermediate or high-risk groups for having OSA as calculated by the STOP-BANG questionnaire
  3. Subjects who have used the following treatments for psoriasis: phototherapy (UVB) in the last 2 weeks, photochemotherapy (PUVA) in the last 4 weeks, oral systemic treatments in the last 4 weeks, biologic immunomodulating agents in the last 12 weeks, or have had exposure to any other investigational drug/device within 30 days prior to study entry
  4. Subjects who have used any over the counter or prescription sleep aids within five half-lives of the agent in question.


  • UCSF Psorisis Center
    San Francisco California 94118 United States

Lead Scientist at UCSF

  • Tina Bhutani, MD, MAS
    I am a dermatologist and clinical researcher in the Department of Dermatology at UCSF. I serve as co-director of the Psoriasis and Skin Treatment Center, a world-renowned clinic dedicated to the care of patients with psoriasis.


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated