Sleep Disorders clinical trials at UCSF
23 in progress, 18 open to eligible people
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
open to eligible people ages 18-75
This study will investigate treatments for insomnia in Veterans who have posttraumatic stress disorder (PTSD). The purpose of this study is to compare a brief behavioral treatment for insomnia (BBTI) to a treatment that helps promote relaxation…
San Francisco, California
Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy
open to eligible females ages 18 years and up
A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.
San Francisco, California and other locations
Lemborexant in Delayed Sleep Phase Syndrome
open to eligible people ages 18 years and up
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2). This will be tracked using sleep logs as well as…
Redwood City, California
Lemborexant in Delayed Sleep Phase Syndrome
open to eligible people ages 18 years and up
The purpose of the study is to evaluate whether Lemborexant is more effective than placebo in shortening sleep onset latency in patients with delayed sleep phase syndrome (both type 1 and type 2). This will be tracked using sleep logs as well as…
San Francisco, California
Lemborexant Shift Work Treatment Study
open to eligible people ages 20-60
Insomnia and daytime sleepiness are common complaints among night shift workers, but effective sleep treatments in shift workers are lacking. The aim of this Phase IV double-blind, placebo-controlled, randomized study is to test whether a dual…
San Francisco, California
Magnetic Apnea Prevention(MAGNAP) Device to Treat Obstructive Sleep Apnea:First-In-Human Study of Feasibility and Safety
open to eligible people ages 21-70
The purpose of this study is to determine the safety and feasibility of the Magnap magnetic device in the treatment of obstructive sleep apnea (OSA).
San Francisco, California
Optimizing an Integrated Mind and Body Treatment for Insomnia: The SLEEPS Study
open to eligible people ages 18 years and up
This single-arm feasibility trial will provide digital cognitive behavioral therapy for insomnia (CBT-I) and passive body heating (PBH) sessions using a sauna blanket over a 9-week treatment period to adults aged 18 years or older with insomnia…
San Francisco, California
Perinatal Research on Improving Sleep and Mental Health
open to eligible females ages 18 years and up
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1. What is the efficacy of digital cognitive behavioral therapy for insomnia (CBT-I) versus digital sleep…
San Francisco, California
Apnea and Insomnia Relief for Veterans With Gulf War Illness
open to eligible people ages 48-80
The purpose of this study is to determine whether a behavioral sleep treatment improves sleep and other Gulf War Illness (GWI) symptoms in Gulf War Veterans with GWI.
San Francisco, California
RCT of a Weighted Blanket to Reduce Pain in Veterans With Chronic Pain
open to eligible people ages 18 years and up
Chronic pain is a major health concern for returning Veterans and is associated with decreases in quality of life. In addition, chronic pain is often accompanied by significant disturbance in sleep. Sensory interventions may offer effective,…
San Francisco, California and other locations
Reaching for Equity in Sleep Apnea Treatment (REST) Study
open to eligible people ages 18 years and up
This study will test a brief telephonic health coaching intervention to improve adherence to positive airway pressure therapy for treatment of obstructive sleep apnea.
San Francisco, California
RECOVER-SLEEP: Platform Protocol
open to eligible people ages 18 years and up
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and…
San Francisco, California and other locations
Remote STATE Training for Insomnia in Older Adults
open to eligible people ages 65 years and up
This study called rSTATE (Remote STATE Training for Insomnia in Older Adults) is a Phase II study to definitively evaluate the efficacy of a computerized cognitive training program (rSTATE) designed to improve sleep regulation and brain health and…
San Francisco, California
Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial
open to eligible females ages 18-40
In this study, the researchers are trying to learn more about the relationship between Polycystic Ovary Syndrome and Obstructive Sleep Apnea (OSA). Obstructive Sleep Apnea is a sleep-related breathing disorder that involves a decrease or complete…
San Francisco, California
Sleep for Stroke Management and Recovery Trial
open to eligible people ages 18 years and up
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6…
San Francisco, California and other locations
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress
open to eligible people ages 18-75
Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair…
San Francisco, California and other locations
The Reducing Risk Study
open to eligible people ages 12-18
The present study will test an innovative mobile health adaptation of a behavioral intervention that improves sleep and mental health concerns among adolescents.
San Francisco, California
Direct Referral for Apnea Monitoring
open to eligible people ages 18 years and up
The primary objective of this project is to compare a health care delivery model, Direct Referral for Apnea Monitoring (DREAM), with initial in-person (Traditional) clinic appointments for Veterans at risk for obstructive sleep apnea (OSA). A…
San Francisco, California and other locations
Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
Sorry, in progress, not accepting new patients
This randomized, double-blind, placebo-controlled trial of doxazosin will assess doxazosin's effectiveness for PTSD nightmares, subjective sleep quality, and non-nightmare PTSD symptoms in adult men and women veterans with full and partial-syndromal …
San Francisco, California
Transdiagnostic Sleep Health Intervention for Veterans With PTSD
Sorry, not yet accepting patients
Sleep disturbance is a major problem in Veterans with posttraumatic stress disorder (PTSD). This study will test a version of a sleep treatment that's been shown to be effective in the general population, with some changes to tailor it to the needs…
San Francisco, California
Orexin Antagonism on Fear Extinction in PTSD
Sorry, not yet accepting patients
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased startle reactivity…
San Francisco, California and other locations
remedē System Therapy Study
Sorry, in progress, not accepting new patients
The purpose of this non-randomized post market study is to collect clinical data on the safety and effectiveness of the remedē System in a real-world setting.
San Francisco, California and other locations
Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia
Sorry, in progress, not accepting new patients
Obstructive sleep apnea (OSA) is a common condition associated with significant adverse health outcomes. Our overarching hypothesis is that patients with OSA and hypoxia (H-OSA) have greater degrees of insulin resistance in both liver and adipose…
San Francisco, California
Our lead scientists for Sleep Disorders research studies include Michael Harrison Jennifer N Felder, PhD Ashley E Mason, PhD Heather Huddleston, MD Anne Richards, MD, MPH Aric Prather, PhD Kathleen Fumiko Sarmiento, MD MPH Andrew D Krystal, MD, MS Jean-Marc Schwarz Rachel Willard-Grace, MPH Sabra S Inslicht, PhD Mary Norton Lauren Asarnow, PhD Linda L Chao, PhD Shira Maguen, PhD.
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