Summary

for people ages 18-75 (full criteria)
at San Francisco, California and other locations
study started
estimated completion:
Sabra S Inslicht

Description

Summary

Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair concentration and memory, and contribute to physical health conditions, such as metabolic syndrome, inflammation, and cardiovascular disease. The orexin neuropeptide system underlies both sleep and stress reactivity. Suvorexant, a drug that reduces orexin, improves sleep in civilians, but has not yet been tested in Veterans with PTSD. This study will test whether suvorexant can improve sleep disturbances and PTSD symptoms in Veterans. Suvorexant may benefit Veterans by improving sleep quickly while also reducing PTSD symptoms over the long term, and with fewer side effects that were common in previous medications used to treat these conditions. Improving Veterans' sleep and PTSD symptoms could lead to better emotional and physical well-being, quality of life, relationships, and functioning.

Official Title

Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance inPosttraumatic Stress

Details

The investigators propose a two-site parallel group, randomized, double-blind, placebo-controlled Phase IV clinical trial to test the efficacy and safety of suvorexant on trauma-related sleep disturbance and PTSD symptoms in Veterans. The investigators will use a flexible dose design of suvorexant with a 2-week titration followed by a 10-week steady-dose phase. The investigators predict that suvorexant, as compared to placebo, will result in a greater decrease in insomnia on the Insomnia Severity Index (ISI) over the 12-week trial. The investigators also predict that suvorexant, as compared to placebo, will result in a greater reduction in non-sleep PTSD symptoms in the Clinician Administered PTSD Scale for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSMV) (CAPS-5) over the 12-week trial. Secondarily, the investigators will examine potential objectively measured wrist actigraphy as a biological mechanism of clinical improvement with as well as concomitant effects on PTSD-related nightmares using the Pittsburgh Sleep Quality Index-PTSD addendum (PSQI-A). Pending a significant effect of suvorexant on PTSD, the investigators will perform exploratory analyses to evaluate whether sleep improvement mediates the effect of suvorexant on PTSD symptoms. The investigators will also examine safety and tolerability of suvorexant compared to placebo (including depression, mood, vigor, suicidality, and daytime somnolence, psychomotor vigilance, and functional disability). Results from this study will provide substantive rationale for the use of Suvorexant in the treatment of Veterans with these concerns. This study will be the first to examine a selective orexin-receptor antagonist in a Veteran sample with PTSD. Suvorexant is an accessible, non-stigmatized medication whose use and safety has been well-established in non-mental-health settings. It has outstanding promise for treating common and distressing symptoms in Veterans as well as civilians with trauma-related sleep disturbance and PTSD.

Keywords

Sleep Initiation and Maintenance Disorders Stress Disorders, Posttraumatic Suvorexant Veterans Disease Stress Disorders, Traumatic Dyssomnias Sleep Wake Disorders Parasomnias Stress Disorders, Post-Traumatic Orexin Receptor Antagonists

Eligibility

You can join if…

Open to people ages 18-75

  • Men and Women, age range of 18 to 75, with a history of US military service, capable of reading and understanding English, and able to provide written informed consent
  • Criterion A event meets DSM-5 criteria and occurred during military service, including combat and military sexual trauma
  • Chronic full syndromal PTSD diagnosis >3 months duration as indexed by CAPS-5 at screening, and CAPS-5 score > 30 CAPS-5 total score for the past week at baseline
  • Insomnia indicated by an ISI score > 14
  • Subjects on non-exclusionary medications must be on a stable dose for at least 4 weeks prior to randomization, which includes the Selective Serotonin Reuptake Inhibitors(SSRIs) e.g.:
  • Sertraline
  • Paroxetine
  • Fluoxetine
  • Fluvoxamine
  • Citalopram
  • Escitalopram
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs), e.g.:
  • Desvenlafaxine
  • Duloxetine
  • Levomilnacipran
  • Venlafaxine
  • For subjects who are in psychotherapy, treatment must be stable for 6 weeks
  • Women of child-bearing potential must not be pregnant or have plans for pregnancy or breastfeeding during the study and must use a medically acceptable method of birth control, e.g.:
  • oral
  • implantable
  • injectable
  • transdermal contraceptive
  • intrauterine device
  • double-barrier method

You CAN'T join if...

  • DSM-5 alcohol, marijuana, and/or other drug use disorder in the last 3 months
  • Mild alcohol and marijuana use not being criteria for use disorder will be allowed
  • Lifetime bipolar disorder I or II, schizophrenia, schizoaffective disorder,obsessive-compulsive disorder, or major depressive disorder with psychotic features
  • Exposure to trauma in the last 3 months
  • Use of exclusionary antidepressant (trazodone, mirtazapine, doxepin, tricyclics), mood stabilizers (e.g., lithium), antipsychotic medication
  • Prominent suicidal or homicidal ideation or any suicidal behavior in the past 3 months on the Columbia Suicide Severity Rating Scale (C-SSRS) or increased risk of suicide that necessitates additional therapy or inpatient treatment
  • Pre-existing sleep apnea in the absence of adherence to effective treatment (such as CPAP or oral device) or positive screen for sleep apnea by type III device
  • Night shift work or extreme morning or evening tendencies in order to avoid the impact of circadian factors on subjective and objective sleep measures
  • Neurologic disorder or systemic illness affecting CNS function
  • Chronic or unstable medical illness including:
  • unstable angina
  • myocardial infarction within the past 6 months
  • congestive heart failure
  • preexisting hypotension or orthostatic hypotension
  • heart block or arrhythmia
  • chronic renal or hepatic failure
  • pancreatitis
  • severe chronic obstructive pulmonary disease
  • History of moderate or severe traumatic brain injury
  • Mild cognitive impairment assessed by the Montreal Cognitive Assessment
  • Pregnancy, breastfeeding and/or refusal to use effective birth control (for women)
  • Previous adverse reaction to a hypnotic
  • Current use of sedative-hypnotics, benzodiazepines, or other drugs used for treating insomnia, strong CYP3A inhibitors, or Digoxin

Prohibited:

  • sedative-hypnotics
  • benzodiazepines
  • strong CYP3A inhibitors
  • Digoxin
  • Mood stabilizers, including:
  • lithium
  • carbamazepine
  • valproate
  • hypnotics
  • neuroleptics or other drugs to treat insomnia will not be allowed because of potential confounding of therapeutic effects
  • Furthermore, CNS depressants (e.g., benzodiazepines, opioids, alcohol) increase the risk of CNS depression when co-administered with suvorexant and will not be allowed for safety reasons.
  • Since metabolism by CYP3A is the major elimination pathway for suvorexant, concomitant use of suvorexant with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole,posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir,indinavir, boceprevir, telaprevir, telithromycin and conivaptan), moderate CYP3A inhibitors (e.g., amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem,erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil), or strong CYP3A inducers (e.g., rifampin, carbamazepine and phenytoin) will not be allowed.
  • All concomitant medication use will be monitored and documented

Locations

  • San Francisco VA Medical Center, San Francisco, CA not yet accepting patients
    San Francisco California 94121 United States
  • Birmingham VA Medical Center, Birmingham, AL not yet accepting patients
    Birmingham Alabama 35233 United States

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
VA Office of Research and Development
ID
NCT03642028
Phase
Phase 4
Lead Scientist
Sabra S Inslicht
Study Type
Interventional
Last Updated