Summary

Eligibility
for females ages 18 years and up (full criteria)
Location
at San Francisco, California and other locations
Dates
study started
completion around
Principal Investigator
by Mary Norton
Headshot of Mary Norton
Mary Norton

Description

Summary

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.

Official Title

A Randomized Trial of Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

Details

Emerging data support a link between sleep disordered breathing (SDB) and adverse pregnancy outcomes. In particular, women with obstructive sleep apnea (OSA) appear to be at increased risk of both hypertensive disorders of pregnancy and gestational diabetes. In the non-pregnant population, OSA is typically treated with continuous positive airway pressure (CPAP) during sleep and has been shown to reduce blood pressure in hypertensive patients. Unfortunately, data on whether maternal and neonatal outcomes could be improved with treatment of OSA during pregnancy are extremely limited. This study aims to address this knowledge gap.

A randomized controlled trial of 1,500 women to assess whether treatment of obstructive sleep apnea with continuous positive airway pressure (CPAP) in pregnancy will result in a reduction in the rate of hypertensive disorders of pregnancy.

Keywords

Obstructive Sleep Apnea of Adult, Preeclampsia, Obstetrical Complications, CPAP, Apnea, pregnancy, Sleep Apnea Syndromes, Obstructive Sleep Apnea, Pre-Eclampsia, Continuous Positive Airway Pressure

Eligibility

Locations

  • Regents of the UCSF accepting new patients
    San Francisco California 94143 United States
  • University of Utah Medical Center accepting new patients
    Salt Lake City Utah 84132 United States

Lead Scientist at UCSF

  • Mary Norton
    Mary E. Norton is a perinatologist and clinical geneticist at UCSF Medical Center's Prenatal Diagnostic Center. She primarily cares for pregnant women who have a fetus with a birth defect or genetic disorder or are at risk for such a condition.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
The George Washington University Biostatistics Center
ID
NCT03487185
Study Type
Interventional
Participants
Expecting 1500 study participants
Last Updated