Diabetes clinical trials at UCSF
36 in progress, 18 open to eligible people
VX-880 in Participants With Type 1 Diabetes
open to eligible people ages 18-65
This study will evaluate the safety, tolerability and efficacy of VX-880 infusion in participants with Type 1 diabetes (T1D) and impaired awareness of hypoglycemia (IAH) and severe hypoglycemia.
San Francisco, California and other locations
Achieving Chronic Care equiTy by leVeraging the Telehealth Ecosystem
open to eligible people ages 18 years and up
This study examines the impact of a multi-level intervention aiming to improve telehealth access for low-income patients managing chronic health conditions, such as hypertension and diabetes. The multi-level intervention includes clinic-level…
San Francisco, California
Continuous Glucose Monitoring System Feasibility in Youth With T2D
open to eligible people ages 8-20
The primary scientific question of this proposal is to investigate whether youth with T2D will wear and interact with a continuous glucose monitor (CGM) system and whether this will influence behavior and management decisions. There will be 30…
San Francisco, California
Device Use Reimagined Through Education And Mentorship
open to eligible people ages 13-17
Diabetes technology, such as insulin pumps and continuous glucose monitoring devices, can help improve glucose control for people with type 1 diabetes (T1D), which keeps them at lower risk for diabetes complications, but many Latinx adolescents, who …
San Francisco, California and other locations
Bolus for Meals in a Closed-loop System
open to eligible people ages 13-19
This study aims to evaluate whether the use of an extended bolus will improve glucose control with high-fat high protein meals using a closed-loop system. The new knowledge gained from this study may provide a method to allow for the proper…
San Francisco, California
Fenofibrate for Prevention of DR Worsening
open to eligible people ages 18-80
This randomized trial will evaluate the effect of fenofibrate compared with placebo for prevention of diabetic retinopathy (DR) worsening through 6 years of follow-up in eyes with mild to moderately severe non-proliferative DR (NPDR) and no CI-DME…
San Francisco, California and other locations
FrexalimAB in Preservation of Endogenous insULIN Secretion Compared to Placebo in adUlts and Adolescents on Top of inSulin Therapy (FABULINUS)
open to eligible people ages 12-35
This is a randomized, parallel group, double-blind Phase 2 study with a 52-week blinded extension evaluating the safety and efficacy of 3 dose levels of frexalimab in comparison with placebo in participants with newly diagnosed T1D on insulin…
San Francisco, California and other locations
Janus Kinase (JAK) Inhibitors to Preserve C-Peptide Production in New Onset Type 1 Diabetes (T1D)
open to eligible people ages 12-35
A multi-center, placebo-controlled, double blind, 1:1:1 randomized control clinical trial testing two different JAK Inhibitors abrocitnib, ritlecitinib, and placebo in subjects with recent onset Stage 3 Type 1 Diabetes within 100 days of diagnosis.
San Francisco, California and other locations
Precision Dosing of Metformin in Youth With T2D
open to eligible people ages 10-21
The purpose of this study to compare the typically prescribed dose of metformin (1000mg twice a day) with a higher dose of metformin (1350mg twice a day).
Oakland, California and other locations
Rituximab-pvvr and Abatacept Vs Rituximab-pvvr Alone in New Onset Type 1 Diabetes
open to eligible people ages 8-45
The study is a two-arm, multicenter, double-blinded clinical trial testing sequential therapy with rituximab-pvvr followed by abatacept versus rituximab-pvvr alone in new onset T1D. The primary objective is to test whether the C-peptide response to…
San Francisco, California and other locations
MiniMed™ 780G System with DS5 CGM in Children
open to eligible people ages 2-6
The purpose of this study is to evaluate the safety of the MiniMed 780G insulin pump used in combination with the DS5 CGM in type 1 pediatric subjects (2-6 years of age) in a home setting.
San Francisco, California and other locations
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
open to eligible people ages 18 years and up
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be…
San Francisco, California and other locations
Commercial or Open Source Closed Loop Impact on Pregnancy Study
open to eligible females ages 18 years and up
The goal of this observational study is to better understand what happens when pregnant people with type 1 diabetes (T1D) use automated insulin delivery (AID) systems. The main questions this study aims to answer are: - What are the maternal and…
San Francisco, California
Designing Team Clinic for Youth with Type 2 Diabetes
open to eligible people ages 12-18
The goal of this clinical trial is to learn about if shared medical appointment is an acceptable way to deliver care to youth with type 2 diabetes. The main question[s] it aims to answer are: - Design four group activities centered around nutrition…
San Francisco, California and other locations
DFC 004 Biomarkers for Active Diabetic Foot Ulcers
open to eligible people ages 18 years and up
This study is a platform study designed to efficiently test multiple biomarkers to identify diabetic foot ulcers (DFUs) with a higher potential for healing versus not healing that ultimately could be applied at the point of care to drive…
San Francisco, California and other locations
Inflammation, Diabetes, Ethnicity and Obesity Cohort
open to eligible people ages 18-75
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years. Obesity is associated with increased mortality through its linkage to comorbidities…
San Francisco, California
TrialNet Pathway to Prevention of T1D
open to eligible people ages 30 months to 45 years
Rationale: The accrual of data from the laboratory and from epidemiologic and prevention trials has improved the understanding of the etiology and pathogenesis of type 1 diabetes mellitus (T1DM). Genetic and immunologic factors play a key role in…
San Francisco, California and other locations
Type 1 Diabetes Extension Study
open to eligible people ages 8-35
This is a multi-center, prospective, non-interventional study that focuses on the long- term effects following participation in selected ITN new-onset Type1 Diabetes Mellitus studies with immunomodulatory agents (T1DM, T1D). This observational study …
San Francisco, California and other locations
Achieving Routine Intervention and Screening for Emotional Health
Sorry, not yet accepting patients
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
Afrezza® INHALE-1 Study in Pediatrics
Sorry, in progress, not accepting new patients
INHALE-1 is a Phase 3, open-label, randomized clinical study evaluating the efficacy and safety of Afrezza in combination with a basal insulin (i.e., the Afrezza group) versus insulin aspart, insulin lispro or insulin glulisine in combination with a …
San Francisco, California and other locations
Automated Insulin for Management of Intrapartum Glycemia
Sorry, not yet accepting patients
The goal of this clinical trial is learn if automated insulin delivery (AID) systems can be used for glucose management during labor/delivery for pregnant people with type 1 diabetes (T1D). The main questions this study aims to answer are - What are …
San Francisco, California
Changing Health Through Food Support for Diabetes
Sorry, in progress, not accepting new patients
This is a pragmatic randomized controlled trial (RCT) of Changing Health through Food Support for Diabetes (CHEFS-DM). This pragmatic RCT will leverage Project Open Hand's (POH) real-world programs to test the impact of a six month medically…
San Francisco, California
DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes
Sorry, not currently recruiting here
This is a non-inferiority patient-centered and pragmatic comparative-effectiveness pregnancy randomized controlled trial (RCT) with postpartum maternal and child follow-up through 2 years of 1,572 individuals with gestational diabetes mellitus (GDM) …
San Francisco, California and other locations
Diabetes Autoimmunity Withdrawn In New Onset and In Established Patients
Sorry, in progress, not accepting new patients
The study is a prospective, randomized, 52-week double-blind, placebo-controlled, multicenter trial in subjects with T1D followed by a 2-year safety follow-up.
San Francisco, California and other locations
Fully Closed Loop At Home (FCL@Home)
Sorry, in progress, not accepting new patients
Protocol Overview/Synopsis This study will be conducted at 3 sites, with each site performing a session with up to 6 participants with a lower HbA1c (<8.0%) in one of 3 age categories (26-60, 18-25, or 14-17 years) followed by a session of up to 6…
San Francisco, California and other locations
Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy
Sorry, not yet accepting patients
The goal of this clinical trial is to learn if patients who have brittle type 1 diabetes receiving an islet transplantation will have better control of their sugars if they also receive one of 2 types of immune cells along with the islet transplant. …
Palo Alto, California
Pancreatic Islets and Parathyroid Gland Co-transplantation for Treatment of Type 1 Diabetes
Sorry, in progress, not accepting new patients
The primary objective is to test the hypothesis that co-transplantation of allogeneic PTG with adult pancreatic islets (derived from same deceased donor) in the IM site in people with Type 1 diabetes with functioning kidney and/or liver transplants…
San Francisco, California
Siplizumab in T1DM
Sorry, in progress, not accepting new patients
This is a multicenter, Phase Ib, open-label, siplizumab dose-finding study in individuals aged 8-45 years with a Type 1 diabetes mellitus (T1DM) diagnosis. within 18 months of V0. Participants will be randomized 1:1:1:1 to one of four possible…
San Francisco, California and other locations
STOP-T1D Low-Dose (ATG)
Sorry, in progress, not accepting new patients
A multi-center, placebo-controlled, double blind, 2:1 randomized control clinical trial testing low-dose ATG vs. placebo in subjects with a 2 year 50% risk of progression to stage 3 T1D.
San Francisco, California and other locations
Student Pharmacist Non-Pharmacological Intervention on Type 2 Diabetes Management in Older Asian Adult Populations
Sorry, not yet accepting patients
This study is being done to assess the impact of student pharmacist involvement on blood glucose control through non-pharmacological interventions in people of Asian and Asian descent over the age of 50 with type 2 diabetes. This study team is…
SYNERGY PLUS: Evaluation of Next Generation Sensors (NGS) and Algorithm in Patients with Type 1 and Type 2 Diabetes
Sorry, not yet accepting patients
The purpose of this study is to find out how well a new continuous glucose monitor works for people with diabetes. This study will test the performance of the study sensor(s) for 7-14 days of wear in patients who are 11-80 years old with type 1 or…
San Francisco, California and other locations
Teplizumab in Pediatric Stage 2 Type 1 Diabetes
Sorry, in progress, not accepting new patients
The purpose of this study is to assess the safety and pharmacokinetics (PK) of teplizumab in participants with Stage 2 type 1 diabetes who are <8 years of age.
San Francisco, California and other locations
Lifestyle Education About Nutrition for Diabetes (Legend) Study
Sorry, in progress, not accepting new patients
This study is being completed to compare two dietary approaches for participants with type 2 diabetes. This research will test whether a very low-carbohydrate or a plate-method diet better improves outcomes for blood glucose control and body…
San Francisco, California and other locations
Treatment of Type I Diabetes by Islet Transplantation Into the Gastric Submucosa Study Protocol
Sorry, in progress, not accepting new patients
The goal of this trial is to gain initial clinical experience regarding the safety and efficacy of treating type I diabetes in people who have received a kidney transplant by transplanting islets into a new transplant site in the stomach…
San Francisco, California
Validation of the Diabetes Deep Neural Network Score for Diabetes Mellitus Screening
Sorry, in progress, not accepting new patients
The Validation of the Diabetes Deep Neural Network Score (DNN score) for Screening for Type 2 Diabetes Mellitus (diabetes) is a single center, unblinded, observational study to clinically validating a previously developed remote digital biomarker,…
San Francisco, California
Recent-Onset Type 1 Diabetes Extension Study Evaluating the Long-Term Safety of Teplizumab (PROTECT Extension)
Sorry, in progress, not accepting new patients
The purpose of this non-interventional extension study is to continue to collect long-term safety and other clinical data for an additional 42 months in participants who completed the PROTECT study.
San Francisco, California and other locations
Our lead scientists for Diabetes research studies include Crystal Zhou, PharmD Andrew M Posselt, MD, PhD Jenise C Wong, MD, PhD Stephen Gitelman, MD Shylaja Srinivasan, MD, MAS Peter Stock, MD, PhD Michael Conte, MD Nasim Sobhani, MD Delphine Tuot Laya Ekhlaspour, MD Suneil Koliwad, MD,PhD Sammy Elmariah, MD, MPH.
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