Brain Injury clinical trials at UCSF
12 in progress, 4 open to eligible people
Brain injury involves harm to the brain from head trauma. UCSF is exploring treatments like brain stimulation for chronic pain and using ultrasound to gather information for better brain injury care. Studies also focus on veterans, aiming to understand emotional challenges from mild brain injuries and how to boost cognitive skills through rehabilitation.
Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain
open to eligible people ages 22-80
Chronic pain affects 1 in 4 US adults, and many cases are resistant to almost any treatment. Deep brain stimulation (DBS) holds promise as a new option for patients suffering from treatment-resistant chronic pain, but traditional approaches target…
San Francisco, California
Mild TBI Assessment & Rehabilitation
open to eligible people ages 18 years and up
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with mild TBI and comorbid conditions. When completed, these studies will inform…
San Francisco, California and other locations
TBI Rehabilitation and Activation in Veterans
open to eligible people ages 50-89
This trial will evaluate the impact of a multicomponent program (TBI Rehabilitation and Activation in Veterans; TRAIN-Vets) on improving cognitive function over an 8-month trial period in older Veterans with traumatic brain injury (TBI). Older…
San Francisco, California and other locations
NOninVasive Intracranial PrEssure from Transcranial DoppLer Ultrasound Development of a Comprehensive Database of Multimodality Monitoring Signals for Brain-Injured Patients
open to eligible people ages 18 years and up
This is an observational study in neurocritical care units at University of California San Francisco Medical Center (UCSFMC), Zuckerberg San Francisco General Hospital (ZSFGH), UC Davis, and Emory University. In this study, the investigators will…
San Francisco, California and other locations
Brain Oxygen Optimization in Severe TBI, Phase 3
Sorry, not currently recruiting here
BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and…
San Francisco, California and other locations
GOALS Cognitive Training Delivered to Aging Veterans in Person or Via Telehealth
Sorry, in progress, not accepting new patients
This study will use technology to deliver effective treatment for cognitive problems associated with TBI to Veterans at home, which may result in improved daily functioning and increased access to health care for the growing population of aging…
San Francisco, California
Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury
Sorry, accepting new patients by invitation only
The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drugs listed below are approved by…
San Francisco, California and other locations
TRACK-TBI Precision Medicine Part 3 - Option II
Sorry, not yet accepting patients
The purpose of this study is to determine if experimental drug treatment improves recovery after TBI as compared to a control (placebo) group. Changes in recovery will be measured throughout the study. The study drug listed below is approved by the…
San Francisco, California
DIAGNOSE CTE Research Project-II
Sorry, accepting new patients by invitation only
Each year, millions of people are exposed to repetitive head impacts (RHI) through contact sports. RHI can result in concussions and asymptomatic non-concussions to confer risk for Alzheimer's disease (AD) and related dementias (ADRD) including…
San Francisco, California and other locations
TRACK-TBI Longitudinal Biomarker Study
Sorry, accepting new patients by invitation only
The overarching goal of this study is to improve understanding of the long-range natural history of TBI by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12 months after injury.
San Francisco, California and other locations
Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Precision Medicine Phase 2 Option 1
Sorry, in progress, not accepting new patients
This study is being conducted to validate early and ultra-early blood-based and novel imaging biomarkers of Diffuse Axonal Injury (DAI), Microvascular Injury (MVI), and neuroinflammation that may serve as predictive and pharmacodynamic biomarkers in …
San Francisco, California and other locations
Transforming Research and Clinical Knowledge in Traumatic Brain Injury Epileptogenesis Project (TRACK-TBI EPI)
Sorry, accepting new patients by invitation only
The overarching goal of this study is to improve understanding of the long-range natural history of TBI and post-traumatic epilepsy (PTE) by extending follow-up of a previously enrolled cohort (TRACK-TBI) beyond the first 12 months after injury.
San Francisco, California and other locations
Our lead scientists for Brain Injury research studies include Geoffrey Manley, MD PhD Prasad Shirvalkar Pratik Mukherjee, MD PhD Kristine Yaffe, MD Erica S. Kornblith, PhD.
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