Expanded NIPT for Pregnancy Complications

a study on Fetal Growth Restriction Preeclampsia

Summary

Eligibility
for females ages 18-60 (full criteria)
Location
at San Francisco, California
Dates
study started
estimated completion
Principal Investigator
by Nasim Sobhani, MD

Description

Summary

This study evaluates the utility of expanded panel non-invasive prenatal testing (NIPT) in detecting confined placental mosaicism of rare autosomal trisomies among pregnancies with placentally-mediated complications, including fetal growth restriction and severe preeclampsia.

Official Title

The Role of Expanded Panel Non-Invasive Prenatal Testing in Identifying Rare Autosomal Trisomies in Pregnancies With Placentally-Mediated Complications

Keywords

Fetal Growth Restriction Preeclampsia Severe Pre-Eclampsia Fetal Growth Retardation Expanded panel cell free DNA testing (non-invasive prenatal testing) Placental biopsy Umbilical cord blood Severe preeclampsia Low PAPP-A

Eligibility

You can join if…

Open to females ages 18-60

  • For fetal growth restriction cohort: diagnosis of early onset (< 34 weeks) severe fetal growth restriction, defined as estimated fetal weight less than 10th percentile with abnormal umbilical artery Dopplers OR estimated fetal weight less than 3rd percentile alone
  • For severe preeclampsia cohort: diagnosis of early onset (< 34 weeks) preeclampsia with severe features, diagnosed by ACOG critiera
  • For low PAPP-A cohort, diagnosis of low PAPP-A levels (pregnancy associated plasma protein A), defined as less than 0.2 multiples of the median
  • For healthy cohort, normal pregnancy with no evidence of maternal, obstetrical, or fetal complications

You CAN'T join if...

  • Maternal age < 18 years
  • Multifetal gestation
  • Chronic hypertension
  • Tobacco or drug use

Location

  • University of California, San Francisco accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Nasim Sobhani, MD
    Assistant Professor, Ob/Gyn, Reproductive Sciences. Authored (or co-authored) 12 research publications.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04311749
Study Type
Observational
Last Updated
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