Opioid Use clinical trials at UCSF
6 in progress, 4 open to eligible people
Opioid use involves taking drugs that may cause addiction. UCSF is comparing the effectiveness of oral versus injectable buprenorphine and office-based methadone versus buprenorphine. UCSF is also researching how opioids affect the eyes and treating veterans with chronic pain who use opioids.
Comparing Oral Buprenorphine and Injectable Buprenorphine for the Treatment of Opioid Use Disorder
open to eligible people ages 18 years and up
VA-BRAVE will determine whether a 28-day long-acting injectable sub-cutaneous (in the belly area) formulation of buprenorphine at a target dose of 300mg is superior in retaining Veterans in opioid treatment and in sustaining opioid abstinence…
San Francisco, California and other locations
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
open to eligible people ages 18-99
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors…
San Francisco, California and other locations
Pain and Opioids: Integrated Treatment In Veterans
open to eligible people ages 21-75
This trial will recruit veterans with chronic pain (N = 160) who are prescribed buprenorphine for the treatment of opioid use disorder (OUD). We seek to: (1) examine the efficacy of an integrated treatment to reduce pain interference and substance…
San Francisco, California and other locations
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
open to eligible people ages 40-60
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60. Previous investigation demonstrated that loss of PUAL was a…
San Francisco, California
Naloxone for Opioid Associated Out of Hospital Cardiac Arrest
Sorry, not yet accepting patients
The investigator's long-term goal is to conduct Naloxone for Opioid Associated out of Hospital Cardiac Arrest (NOPACA), a randomized, double blind, controlled trial to determine the efficacy of naloxone vs. placebo in Opioid Associated out of…
San Francisco, California
Naltrexone for Overdose Prevention
Sorry, not yet accepting patients
The goal of this clinical trial is to see if an injectable medicine called naltrexone can prevent fentanyl overdose deaths in people who use other drugs (cocaine, methamphetamine). The main questions it aims to answer are: What are the challenges…
San Francisco, California
Our lead scientists for Opioid Use research studies include Andy Tompkins, MD Ayesha Appa, MD Rachel Eshima McKay, MD Ralph Wang, MD, MAS Paula Lum, MD.
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