Summary

Eligibility
for people ages 18-70 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
estimated completion
Principal Investigator
by John Fahy, MD, MSc
Photo of John Fahy
John Fahy

Description

Summary

This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" [VNB]) to sample airway biospecimens in mucus plugged and control airways.

Details

This is a single center study of 60 subjects. The investigators will enroll 30 subjects with asthma who demonstrate mucus plugging on a screening CT lung scan, 15 subjects with asthma without mucus plugging, and 15 healthy controls. The healthy controls and subjects with asthma but without mucus plugging with also undergo CT scans to confirm that their lungs aren't obstructed by mucus.

Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" [VNB]) to sample airway biospecimens in mucus plugged and control airways. Subjects will participate in up to 5 study visits at the Airway Clinical Research Center.

Keywords

Asthma Mucus; Plug, Tracheobronchial Mucus Plug Bronchoscopy CT Scan Multidetector Computed Tomography (MDCT) Scan Virtual Navigation Bronchoscopy (VNB)

Eligibility

For people ages 18-70

Group 1: Healthy Controls

Inclusion Criteria:

  • Male or female between the ages of 18 and 70 years at Visit 1 and at least 50% whose age is > 40 years (to ensure age balance among groups and anticipating that group 3 subjects will be older).
  • Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
  • Able to perform reproducible spirometry according to ATS criteria.

Exclusion Criteria:

  • Upper respiratory tract infection (URI) within the previous 6 weeks.
  • History of lung disease.
  • Smoking of tobacco or other recreational inhalants in last month and/or >10 pack-year smoking history.
  • Currently pregnant.
  • History of allergic rhinitis.
  • Laboratory evidence of atopy (blood eosinophils > 0.4 cells/dL, IgE > 165 IU/mL)
  • History of unstable cardiovascular disease.
  • BMI > 45
  • Currently taking anticoagulants.

Group 2: Asthmatic Subjects without Mucus Plugs

Inclusion Criteria:

  • Male or female between the ages of 18 and 70 years at Visit 1 and at least 50% whose age is > 40 years (to ensure age balance among groups and anticipating that group 3 subjects will be older).
  • Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
  • Able to perform reproducible spirometry according to ATS criteria.
  • Physiological evidence of airflow obstruction (FEV1 bronchodilator reversibility of ≥ 12% or hyperreactivity to methacholine reflected by a methacholine PC20 ≤ 16 mg/mL). Historical methacholine data from previous studies conducted in the past 5 years at the UCSF ACRC will be allowed.
  • Clinical history of asthma per patient report or medical record.
  • Asthma requiring treatment with inhaled corticosteroids (ICS) for 3 months or greater.

Exclusion Criteria:

  • Asthma exacerbation or URI within the previous 6 weeks.
  • Currently pregnant.
  • Smoking of tobacco or other recreational inhalants in last month and/or >10 pack-year smoking history.
  • Other chronic pulmonary disorders, including cystic fibrosis and chronic obstructive pulmonary disease.
  • History of unstable cardiovascular disease.
  • BMI > 45.
  • Currently taking anticoagulants.

Group 3: Asthmatic Subjects with Mucus Plugs

Inclusion:

  • Male or female between the ages of 18 and 70 years at Visit 1.
  • Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
  • Able to perform reproducible spirometry according to ATS criteria.
  • Physiological evidence of airflow obstruction (FEV1 bronchodilator reversibility of ≥ 12% or hyperreactivity to methacholine reflected by a methacholine PC20 ≤ 16 mg/mL). Historical methacholine data from previous studies conducted in the past 5 years at the UCSF ACRC will be allowed.
  • Clinical history of asthma per patient report or medical record.
  • Asthma requiring treatment with inhaled corticosteroids (ICS) for 3 months or greater.
  • A MDCT lung scan indicating a mucus plug accessible by bronchoscopy in at least one airway.

Exclusion Criteria:

  • Asthma exacerbation or URI within the previous 6 weeks.
  • Currently pregnant.
  • Smoking of tobacco or other recreational inhalants in last month and/or >10 pack-year smoking history.
  • Other chronic pulmonary disorders, including cystic fibrosis and chronic obstructive pulmonary disease.
  • History of unstable cardiovascular disease.
  • BMI > 45.
  • Currently taking anticoagulants.
  • Mucus plugs inaccessible by bronchoscope.

Location

  • UCSF Airway Clinical Research Center
    San Francisco California 94143 United States

Lead Scientist at UCSF

  • John Fahy, MD, MSc
    I am a Professor of Medicine in the Division of Pulmonary and Critical Care Medicine and the Department of Medicine at UCSF. I direct a research program in asthma and other airway diseases that is human centered and focused on uncovering disease mechanisms and improving treatment.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
Links
Airway Clinical Research Center website
ID
NCT04514913
Study Type
Observational
Last Updated