Atopic Dermatitis (Eczema) clinical trials at UCSF

4 in progress, 2 open to eligible people

Atopic dermatitis, also called eczema, is a skin disease that makes skin red, dry, and itchy. UCSF is studying how blocking IL4RA with dupilumab changes immune cells in eczema lesions. UCSF is also measuring skin sodium in adults aged 50 and older with and without eczema.

Showing trials for

  • Molecular Signatures of Cutaneous Dupilumab Response

    open to eligible people ages 18 years and up

    This study examines the effect of IL4RA blockade with dupilumab on the immune cells of atopic dermatitis skin lesions.

    San Francisco, California

  • Sodium in the Skin and Atopic Dermatitis

    open to eligible people ages 50 years and up

    The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.

    San Francisco, California and other locations

  • Dietary Salt on the Severity of Eczema

    Sorry, not yet accepting patients

    The goal of this clinical trial is to evaluate the feasibility of low-sodium diet to improve eczema severity. The main questions it aims to answer are: - Does a low-sodium diet improve eczema severity? - How does a low-sodium diet impact skin sodium concentration? - Is skin sodium concentration associated with eczema severity? Researchers will ask all participant to follow a low-sodium diet, then compare sodium tablets to a placebo (a look-alike substance that contains no drug) to specifically examine the impact of altering sodium intake. Participants will: - Follow a low-salt diet for the duration of the 24-week study - Take sodium chloride tablets every day for 5 weeks followed by a placebo every day for 5 weeks after a 2-week washout period, or vice versa - Complete up to 4 virtual check-in visits - Visit the clinic 4 times to answer questionnaires, provide bio samples, complete dietary recalls, and undergo non-contrast sodium MRI

    San Francisco, California and other locations

  • Utilization of a Microdevice for Psoriasis and Atopic Dermatitis

    Sorry, not yet accepting patients

    This study is being done to test a microdevice, which is a small device designed to test drugs directly on skin conditions like atopic dermatitis (eczema) and psoriasis. The small device, about the size of a grain of rice, has up to 20 tiny reservoirs that hold medications that are approved by the Food and Drug Administration (FDA) for atopic dermatitis and psoriasis. Very small amounts of these medications will be released into the skin (at levels in your body much lower than are typically used). In this study, the device will be tested to see if it's safe and works well for predicting how the skin will react to standard treatments. We will also look at how these reactions are connected to genetic information and overall treatment results.

    San Francisco, California

Our lead scientists for Atopic Dermatitis (Eczema) research studies include .

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