for people ages 18 years and up (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Clark Rosen, MD
Headshot of Clark Rosen
Clark Rosen



Spasmodic Dysphonia (SD) is a neurologic condition causing inappropriate contraction of the laryngeal musculature, leading to abnormal voicing. The three types (adductor, abductor, and mixed) affect varying muscle groups which produce characteristic voice patterns. The vast majority of patients with SD have adductor type, which impacts the lateral cricoarytenoid and thyroarytenoid muscle complex. While many treatment modalities have been investigated, the most effective treatment is botulinum toxin injection to these muscle groups, performed transcervically with or without electromyography (EMG) guidance. Patients undergoing this treatment typically require re-injection every 3 months. Due to its specialized nature, the laryngeal injections are not performed routinely outside of academic medical centers; thus, patients may come from a distance to receive this treatment. Both due to the significant impact on voice quality when the injections wear off and the sometimes challenging access to treatment, a longer-acting agent is desired.

Injectible daxibotuliumtoxinA (DAXI, Revance Therapeutics Inc., Newark, CA) has been shown in large clinical trials to provide safe, effective treatment for glabellar lines and cervical dystonia and may offer a longer-lasting result when compared with onabotulinumtoxinA.

Thus, a study examining the effect of DAXI for patients with adductor spasmodic dysphonia is proposed. This study aims to assess the efficacy of DAXI for transcervical laryngeal injection in patients with adductor spasmodic dysphonia.


Adductor Spasmodic Dysphonia, Voice Disorders, Spasmodic Dysphonia, Dysphonia, Hoarseness, Type A Botulinum Toxins, abobotulinumtoxinA, DaxibotulinumtoxinA, Administration of Daxi


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Open to people ages 18 years and up

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  • UCSF accepting new patients
    San Francisco California 94118 United States

Lead Scientist at UCSF

  • Clark Rosen, MD
    Clark Rosen, MD is a Director of the UCSF Voice and Swallowing Center, Chief of the Division of Laryngology, Professor of Otolaryngology-Head and Neck Surgery. Dr. Rosen is originally from Los Gatos, California and is a proud graduate of Cal (Go Bears!).


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Phase 1/2 Spasmodic Dysphonia Research Study
Study Type
Expecting 20 study participants
Last Updated