Cancer, General clinical trials at UCSF
38 in progress, 26 open to eligible people
Cancer is a disease where cells grow uncontrollably. UCSF is studying new treatments for kids with stubborn cancer and testing a tablet for adults with solid tumors. Other trials focus on music therapy during leukemia treatment and finding lung cancer risks using biomarkers.
9-ING-41 in Pediatric Patients with Refractory Malignancies.
open to eligible people ages up to 22 years
9-ING-41 has anti-cancer clinical activity with no significant toxicity in adult patients. This Phase 1 study will study its efficacy in paediatric patients with advanced malignancies.
San Francisco, California and other locations
NST-628 Oral Tablets in Subjects With Solid Tumors
open to eligible people ages 18 years and up
This is a two-part Phase 1, open label, multi-center, single arm, non-randomized, multiple dose, safety, pharmacokinetic (PK) and preliminary efficacy study of single agent NST-628 in adult patients with MAPK pathway mutated/dependent advanced solid …
San Francisco, California and other locations
Biology and Benefits of Music Play and Stories for Kids/Parents During ALL Treatment
open to eligible people ages 3-8
Music therapy has become a standard palliative care service in many pediatric and adult hospitals; however, a majority of music therapy research has focused on the use of music to improve psychosocial dimensions of health, without considering…
Oakland, California and other locations
ChangeGradients: Promoting Adolescent Health Behavior Change
open to eligible people ages 15-17
As most adolescents visit a healthcare provider once a year, health behavior change interventions linked to clinic-based health information technologies hold significant promise for improving healthcare quality and subsequent behavioral health…
San Francisco, California
Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer
open to eligible people ages 18 years and up
This cluster-randomized comparative effectiveness trial compares a technology-based supportive cancer care (SCC) approach with a redesigned team-based supportive cancer care (SCC) approach.
San Francisco, California and other locations
Whole Body DWI to FDG PET
open to eligible people ages 18 years and up
This is a single arm prospective trial that evaluates whole body diffusion weight imaging (DWI) compared to 18F-fludeoxyglucose (FDG) Positron Emission Tomography with Magnetic resonance imaging (PET/MRI) in participants with known metastatic…
San Francisco, California
Imaging of Solid Tumors Using FAP-2286
open to eligible people ages 18 years and up
This is a multi-arm prospective trial that evaluates the ability of a novel imaging radiolabeled agents to detect metastatic cancer in participants with solid tumors using a gallium 68 (68Ga-) or copper 64 (64Cu-) FAP-2286 tracer. FAP-2286 is a…
San Francisco, California
Improving Cognition and Behavior in Pediatric Cancer Survivors Using a Novel Mindful Attention Training
open to eligible people ages 7-17
This pilot study will evaluate the cognitive and behavioral outcomes of using a novel, adaptive attention training in pediatric cancer survivors.
San Francisco, California
Intra-Tumoral Injections of Natural Killer Cells for Recurrent Malignant Pediatric Brain Tumors
open to eligible people ages 1-38
This phase I trial tests the safety, side effects, and best dose of ex vivo expanded natural killer cells in treating patients with cancerous (malignant) tumors affecting the upper part of the brain (supratentorial) that have come back (recurrent)…
San Francisco, California and other locations
Mobile App to Help Survivors of Childhood Cancer Navigate Long-Term Follow-Up Care
open to all eligible people
This clinical trial studies the effectiveness of a newly developed survivorship mobile application (app) designed for survivors, or their caregivers, of childhood cancer to help them better navigate long-term follow-up care. The survivorship app…
San Francisco, California
Implementation of COMPRENDO
open to eligible people ages 18 years and up
COMPRENDO (ChildhOod Malignancy Peer Research NavigatiOn) is a multi-site randomized clinical trial (RCT) that uses a Hybrid Type 1 design, to test the effects of a clinical intervention on patient-level outcomes, while exploring multilevel…
San Francisco, California and other locations
National Liver Cancer Screening Trial
open to eligible people ages 18-85
The National Liver Cancer Screening Trial is an adaptive randomized phase IV Trial comparing ultrasound-based versus biomarker-based screening in 5500 patients with cirrhosis from any etiology or patients with chronic hepatitis B infection. Eligible …
San Francisco, California and other locations
Pan Tumor Rollover Study
open to eligible people ages 18 years and up
Main Objective of this study is to examine long-term safety of nivolumab monotherapy including combinations and other cancer therapies in various tumor types.
San Francisco, California and other locations
Preoperative Immunotherapy in Patients With Squamous Cell Carcinoma of the Head and Neck
open to eligible people ages 18 years and up
To determine the effect of neoadjuvant atezolizumab alone or in combination with other immune modulating agents on T-cell infiltration in advanced SCCHN. To determine the impact of neo-adjuvant immunotherapy on surgical outcomes.
San Francisco, California
RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
open to eligible people ages 30 months to 18 years
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents. Most children receiving highly emetogenic chemotherapy (HEC), including those receiving…
San Francisco, California and other locations
PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
open to eligible people ages 18 years and up
This is a first-in-human (FIH), open label Phase 1/1b / Phase 2 study in patients with advanced metastatic solid tumors refractory to standard treatment. Phase 1 will identify potential optimal biologically relevant doses (OBRD) and the maximum…
San Francisco, California and other locations
Avutometinib (VS-6766) +Defactinib With Gemcitabine and Nab-paclitaxel in Patients With Pancreatic Cancer
open to eligible people ages 18 years and up
This study will assess the safety and efficacy of avutometinib (VS-6766) and defactinib in combination with gemcitabine and nab-paclitaxel in patients with Pancreatic Ductal Adenocarcinoma (PDAC) who have been previously untreated.
San Francisco, California and other locations
RP1 Monotherapy and RP1 in Combination With Nivolumab
open to eligible people ages 18 years and up
RPL-001-16 is a Phase 1/2, open label, dose escalation and expansion clinical study of RP1 alone and in combination with nivolumab in adult subjects with advanced and/or refractory solid tumors, to determine the maximum tolerated dose (MTD) and…
San Francisco, California and other locations
Tobacco Cessation Care for Cancer Patients by Automated Interactive Outreach
open to eligible people ages 18 years and up
This is a multi-arm, randomized controlled, pilot study which will recruit cancer patients who have been seen by a UCSF Cancer Center-affiliated clinical department to evaluate the efficacy of "CareConnect". This is the first study to assess the…
San Francisco, California
Women Informed to Screen Depending on Measures of Risk (Wisdom Study)
open to eligible females ages 30-74
Most physicians still use a one-size-fits-all approach to breast screening in which all women, regardless of their personal history, family history or genetics (except BRCA carriers) are recommended to have annual mammograms starting at age 40.…
San Francisco, California and other locations
Biomarkers for Risk Stratification in Lung Cancer
open to eligible people ages 40 years and up
This is a prospective observational study that will follow patients who undergo lung cancer screening at the San Francisco VA Medical Center, University of California, San Francisco (UCSF) Medical Center, and the San Francisco General Hospital. The…
San Francisco, California and other locations
Childhood Cancer Survivor Study
open to all eligible people
The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the…
San Francisco, California and other locations
Discovering Cancer Risks From Environmental Contaminants and Maternal/Child Health
open to eligible people ages 18 years and up
The DREAM Cohort is a longitudinal observational study developed to enhance our understanding of how multiple exposures to environmental chemicals and pollutants across a diverse population of pregnant women and their offspring are linked to cancer…
Fresno, California and other locations
Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRT
open to eligible people ages 18 years and up
Cancer-related fatigue (CRF) is a significant problem for cancer patients. This prospective, basic science, observational study will evaluate for changes in CRF associated with molecular characteristics prior to, during, and at the completion of…
San Francisco, California
Pancreatic Cancer Screening
open to eligible people ages 18 years and up
This study investigates how often abnormal findings from routine magnetic resonance imaging occur in people with genetic mutations in BReast CAncer gene. (BRCA), ataxia telangiectasia mutated gene (ATM), or PALB2 screened for pancreatic cancer. This …
San Francisco, California
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
open to eligible people ages 0 years and up
Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females. Recently targeted drugs that block many of the genetic drivers of DTC have become…
San Francisco, California and other locations
Cancer Treatment With Balstilimab (AGEN2034) and Zalifrelimab (AGEN1884)
Sorry, not accepting new patients
This is an expanded access study for cancer treatment with balstilimab alone or in combination with zalifrelimab for an intermediate-size participant population. This study addresses the treatment needs of participants who have been previously and…
San Francisco, California and other locations
(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors
Sorry, in progress, not accepting new patients
This is a Phase 3, open-label, international, multicenter study of CGT9486 in combination with sunitinib. This is a multi-part study that will enroll approximately 442 patients. Part 1 consists of two evaluations: 1) confirming the dose of an…
San Francisco, California and other locations
9-ING-41 in Patients with Advanced Cancers
Sorry, in progress, not accepting new patients
GSK-3β is a potentially important therapeutic target in human malignancies. The Actuate 1801 Phase 1/2 study is designed to evaluate the safety and efficacy of 9-ING-41, a potent GSK-3β inhibitor, as a single agent and in combination with cytotoxic…
San Francisco, California and other locations
Ramucirumab (LY3009806) or Merestinib (LY2801653) in Advanced or Metastatic Biliary Tract Cancer
Sorry, in progress, not accepting new patients
The main purpose of this study is to evaluate the efficacy and safety of ramucirumab or merestinib or placebo plus cisplatin and gemcitabine in participants with advanced or metastatic biliary tract cancer.
San Francisco, California and other locations
APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors
Sorry, not currently recruiting here
To assess: - efficacy of APL-101 as monotherapy for the treatment of NSCLC harboring MET Exon 14 skipping mutations, NSCLC harboring MET amplification, solid tumors harboring MET amplification, solid tumors harboring MET fusion, primary CNS tumors…
San Francisco, California and other locations
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Sorry, in progress, not accepting new patients
This is a 2 strata pilot trial within the Pacific Pediatric Neuro-Oncology Consortium (PNOC). The study will use a new treatment approach based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500…
San Francisco, California and other locations
Lung Cancer Screening CT for Firefighters
Sorry, not yet accepting patients
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational exposures such as…
San Francisco, California
LVGN6051 as Single Agent and in Combination With Keytruda (Pembrolizumab) in Advanced or Metastatic Malignancy
Sorry, in progress, not accepting new patients
LVGN6051 is a humanized monoclonal antibody that specifically binds to CD137, and acts as an agonist against CD137. This first in human study of LVGN6051 is designed to establish the maximum tolerated dose (MTD) and/or the recommended dose for…
San Francisco, California and other locations
Nab-sirolimus in Patients With Malignant Solid Tumors With Pathogenic Alterations in TSC1/TSC2 Genes (PRECISION 1)
Sorry, in progress, not accepting new patients
A Phase 2 multi-center open-label basket trial of nab-sirolimus for adult and adolescent patients with malignant solid tumors harboring pathogenic inactivating alterations in TSC1 or TSC2 genes
San Francisco, California and other locations
Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer
Sorry, in progress, not accepting new patients
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from …
San Francisco, California and other locations
Avutometinib (VS-6766) + Adagrasib in KRAS G12C NSCLC Patients
Sorry, in progress, not accepting new patients
This study will assess the safety and efficacy of avutometinib (VS-6766) in combination with adagrasib in patients with G12C Non-Small Cell Lung Cancer (NSCLC) who have been exposed to prior G12C inhibitor and experienced progressive disease.
San Francisco, California and other locations
Prostate Cancer Screening for People at Genetic Risk for Aggressive Disease, PATROL Study
Sorry, not currently recruiting here
This study investigates ways to detect prostate cancer earlier in people at genetic risk for disease that forms, grows, or spreads quickly (aggressive). Studying samples of blood, urine, and/or tissue in the laboratory may help doctors further…
San Francisco, California and other locations
Our lead scientists for Cancer, General research studies include Pamela Munster Peggy Reynolds, PhD Mehrdad Arjomandi, M.D. Jennifer Michlitsch, MD Sabine Mueller Robert Goldsby, MD Laura Esserman, MD, MBA Katy Tsai, MD Janice Tsoh Andrew Ko Varun Monga Joaquin Anguera, PhD Elizabeth Ozer, PhD Sue Yom, MD Christopher Dvorak Alain Algazi Jae Ho Sohn, MD, MS Thomas Hope Kieuhoa Vo, MD Matthew Cooperberg, MD, MPH Neil Mehta, MD.
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