for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
completion around
Principal Investigator
by Vadim Koshkin
Headshot of Vadim Koshkin
Vadim Koshkin



This study is being done to learn about urothelial cancers that make HER2 and how that affects treatment choices for participants with urothelial cancer. During this study, the medical and health records of participants will be reviewed to learn more about their health.

Participants will have urothelial cancer that has grown in the body near where it started (locally advanced) and cannot be removed (unresectable) or has spread through the body (metastatic).

Official Title

A Retrospective Chart Review of Real-world Treatment Outcomes in Patients With Locally Advanced Unresectable or Metastatic Urothelial Cancer Based on HER2 Expression


Urothelial Carcinoma, Urothelial Cancer, Bladder Cancer, HER2 Mutations, HER2 Overexpression, HER2 Amplification, Seattle Genetics, Transitional Cell Carcinoma


You can join if…

Open to people ages 18 years and up

  • Histologically confirmed UC originating from the renal pelvis, ureters, bladder, or urethra. Mixed-cell type tumors are eligible as long as urothelial cell carcinoma is the predominant cell type.
  • Locally advanced unresectable or metastatic stage disease
  • Formalin fixed paraffin embedded (FFPE) tumor tissue blocks (or freshly sectioned slides, see laboratory manual for details) available for HER2 testing.
  • At least 1 prior line of systemic therapy for locally advanced unresectable or metastatic urothelial carcinoma (LA/mUC), including 1 line of platinum-containing chemotherapy.
  • Initiation of anticancer therapy for UC after prior progression on platinum-based therapy with or without maintenance avelumab between 01 January 2019 and 12 months before the end of data collection
  • Radiographically documented and measurable disease progression immediately before index date

You CAN'T join if...

  • Any concurrent malignant neoplasm requiring systemic therapy during the study window
  • Enrollment in a therapeutic clinical trial and received non-standard of care treatment during index line of therapy


  • UCSF accepting new patients
    San Francisco California 94158 United States
  • University of California Irvine accepting new patients
    Orange California 92868 United States

Lead Scientist at UCSF

  • Vadim Koshkin
    I am a genitourinary medical oncologist and in this capacity I specialize in caring for patients with bladder, prostate, kidney and testicular cancers.


accepting new patients
Start Date
Completion Date
Seagen Inc.
Study Type
Expecting 350 study participants
Last Updated