for people ages 12-18 (full criteria)
study started
completion around
Principal Investigator
by Lauren Asarnow, Ph.D.
Headshot of Lauren Asarnow
Lauren Asarnow



The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable target, improves depression outcomes in a subgroup of adolescents with depression and a misaligned relationship between biological circadian timing and waketime utilizing a cognitive-behavioral sleep intervention.

Official Title

A Confirmatory Efficacy Trial of Engaging a Novel Sleep/Circadian Rhythm Target as Treatment for Depression in Adolescents


Depression in Adolescence, Delayed Sleep Phase, Depression, Adolescents, Sleep, Intervention, Depressive Disorder, TranS-C, Psychoeducation


For people ages 12-18

Inclusion Criteria:

Exclusion Criteria:

  • mental health/behavioral symptoms that would preclude productive engagement in study assessments or intervention (e.g., active psychosis; Bipolar Disorder; drug dependence
  • severe or unstable medical or psychiatric condition such that treatment has changed within the last month or is expected to change during the course of the study or that would preclude ability to adhere to study procedures (e.g. terminal end-stage cancer)
  • current use of medications or herbs with known effects on sleep
  • plan to undergo or have had medication change in the last 8 weeks

Lead Scientist at UCSF

  • Lauren Asarnow, Ph.D.
    Dr. Asarnow’s research program aims to reduce the burden of mental illness in youth by developing behavioral interventions that are effective, youth friendly, engaging, widely disseminable and easily accessible. Her program of research has primarily focused on sleep as a potential target for intervention in the prevention and treatment of mental and physical health problems.


not yet accepting patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 200 study participants
Last Updated