Urethral Stricture clinical trials at UCSF

2 in progress, 1 open to eligible people

Urethral stricture is a condition where the tube that carries urine out of the body becomes narrow. UCSF is studying pain control methods for patients who have surgery to fix this problem using tissue from the mouth. These studies help understand how to reduce pain after surgery.

Showing trials for

  • Peri-operative Oral Pain Control Following Buccal Graft Urethroplasty

    open to eligible males ages 18 years and up

    Patients undergoing buccal urethroplasty will often have significant post-operative oral pain from the graft site. Various graft harvest techniques and methods for post-harvest hemostasis including graft site closure have been explored. Despite the frequency of this clinical scenario there is no established best practice for peri-operative pain management in this patient population. In addition to traditional post operative pain control, groups have sought various peri-operative anesthetic regimens to improve post operative pain. This has led recently to the description of various regional blocks including buccal and periorbital blocks for peri-operative local anesthetic. No study has looked at superiority of regional pain management in this patient population. This study will aim to assess three established anesthetic protocols for oral pain control in a blinded, randomized controlled trial. Hypothesis: Patients who have buccal block will have lower post op pain without any increase adverse oral outcomes.

    San Francisco, California and other locations

  • Autologous Engineered Urethral Constructs for the Treatment of Strictures

    Sorry, not currently recruiting here

    This is a Phase I clinical study to determine the safety and efficacy of using autologous, engineered urethral constructs for the treatment of urethral strictures in adult males. The proposed study design is a prospective non-randomized and uncontrolled single-center investigation. Autologous urothelial cells (UCs) and smooth muscle cells (SMCs), obtained from enrolled male subjects' bladder tissue samples, will be culture expanded in vitro and used to seed tubular PGA scaffolds to create autologous urethral constructs for the repair of urethral strictures.

    San Francisco, California and other locations

Our lead scientists for Urethral Stricture research studies include .

Last updated: