PrEP clinical trials at UCSF

3 research studies open to eligible people

PrEP is a way to prevent HIV. At UCSF, we're studying how text messaging can help people use PrEP better. We're also looking at how PrEP use is affected by mood changes in men who use stimulants. Lastly, we're exploring how to help young men stick with their PrEP routine.

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  • Comparing Mobile Health Strategies to Improve Pre-exposure Prophylaxis Use (PrEP) for HIV Prevention

    open to eligible people ages 15 years and up

    The purpose of this study is to compare the effectiveness of two mobile health technologies (text messaging or a mobile app) designed to help people take HIV pre-exposure prophylaxis (PrEP) as directed by the clinic. PrEP is the use of a daily anti-HIV medications by HIV-negative people to help prevent HIV infection.

    San Francisco, California and other locations

  • PrEP Affect Regulation Treatment Innovation

    open to eligible males ages 18 years and up

    This multi-site randomized controlled trial enrolling sexual minority men who use stimulants and are currently taking pre-exposure prophylaxis (PrEP). This randomized controlled trial will test the efficacy of a PrEP Affect Regulation Treatment Innovation (PARTI) condition comprised of a 5-session positive affect intervention delivered during smartphone-based Contingency Management (CM) for directly observed PrEP doses (PARTI+CM) compared to an attention-control condition delivered during CM. The primary outcome is HIV acquisition risk measured using a combination of tenofovir-diphosphate levels in dried blood spots that are indicative of sub-optimal adherence to PrEP and recent condomless anal sex.

    San Francisco, California and other locations

  • PrEP Point-of-Care Brief-Intervention for Adherence Among Young Men Who Have Sex With Men

    open to eligible males ages 18-30

    Despite advances in HIV prevention, the HIV incidence among young men who have sex with men (YMSM) is increasing, threatening to derail achievement of the United States End the HIV Epidemic goals. Although, pre-exposure prophylaxis (PrEP) is a highly effective HIV prevention method, adherence was sufficiently low to comprise efficacy among a high proportion of YMSM in multiple clinical trials and demonstration projects. In this study, the investigators will leverage a novel urine point-of-care drug-level test for PrEP adherence, to both enhance and target motivational-interviewing-based adherence counseling among YMSM, with the goal of preventing HIV infections among this critically at-risk group.

    San Francisco, California

Our lead scientists for PrEP research studies include .

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