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Healthy Volunteers
healthy people welcome
Location
at San Francisco, California and other locations
Dates
study started
estimated completion:
Principal Investigator

Description

Summary

The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.

Details

The study will focus on the following objectives:

  • Characterize survivors' health with respect to disease- and treatment-related factors.
  • Investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc…).
  • Compare the mortality experience of survivors with the general population.
  • Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors.
  • Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes.
  • Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.

Keywords

Cancer Childhood cancer Young Children Adults

Eligibility

You can join if…

Initial Cohort:

  • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,Wilms tumor, neuroblastoma, or soft tissue sarcoma before age 21 years between January 1, 1970 and December 31, 1986 at one of participating centers.

Expanded cohort:

  • Five-year survival following diagnosis of leukemia, lymphoma, CNS tumor, bone tumor,kidney tumor, neuroblastoma, or rhabdomyosarcoma before age 21 years between January 1, 1987 and December 31, 1999 at one of participating centers.
  • English- or Spanish-speaking and living in the U.S. or Canada at the time of diagnosis.

You CAN'T join if...

  • Diagnosis of non-malignant tumors (i.e., Langerhans cell histiocytosis, meningioma,craniopharyngioma, etc.) treated with radiation and/or chemotherapy.
  • Non-English speaking or residence outside the US or Canada.

Sibling Controls:

  • For comparison purposes, a group of sibling controls will be identified to represent a stratified random sample based on the distribution of survivors with regard to cancer diagnosis, age, sex, race, and geographic location.

Locations

  • Stanford University School of Medicine accepting new patients
    Stanford, California, 94305, United States
  • Children's Hospital Los Angeles accepting new patients
    Los Angeles, California, 90027, United States
  • City of Hope National Medical Center accepting new patients
    Duarte, California, 91010, United States
  • University of California-Los Angeles accepting new patients
    Los Angeles, California, 90095, United States
  • Children's Hospital of Orange County accepting new patients
    Orange, California, 92868, United States

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
St. Jude Children's Research Hospital
Links
St. Jude Children's Research Hospital
Long-Term Follow-Up Study
Clinical Trials Open at St. Jude
ID
NCT01120353
Lead Scientist
Robert Goldsby
Study Type
Observational
Last Updated
February 1, 2017
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