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Summary

for people ages 18 years and up (full criteria)
at San Francisco, California
study started
estimated completion:

Description

Summary

This is a single-arm, open-label study, which will examine the effect of dupilumab on the immunologic and genetic environment within atopic dermatitis lesions.

Details

This is a single center, open-label study, which will examine the effect of dupilumab on the immunologic and genetic environment within atopic dermatitis (AD) lesions. Fifteen subjects with moderate to severe AD will receive dupilumab for a treatment period of 52 weeks (i.e. last injection on week 48). Surgical discard specimens will also be collected from fifteen healthy subjects. Biopsy samples from AD subjects and surgical discard samples will undergo molecular profiling. Skin swabs and stool samples will be collected and banked for future analysis. The reason to treat patients for 52 weeks is to have the ability to correlate early molecular events with clinical outcomes (EASI, IGA, itch score) at week 52. In addition, collection of microbiome samples will be performed at week 52.

Keywords

Atopic Dermatitis Atopic Dermatitis Eczema eczema dupilumab Dermatitis Dermatitis, Atopic

Eligibility

You can join if…

Open to people ages 18 years and up

  • Ability to provide written informed consent and comply with the protocol.
  • At least 18 years of age.
  • Diagnosis of chronic atopic dermatitis for at least 3 years prior to enrollment.
  • Subject is considered a candidate for phototherapy or systemic therapy
  • Eczema Area and Severity Index (EASI) score ≥ 16
  • Investigator Global Assessment (IGA) ≥ 3
  • 10% body surface area (BSA) or greater
  • Subject is unlikely to conceive due to male, post-menopausal, or using adequate contraceptive (barrier, hormonal, implant, or permanent sterilization methods).
  • Physical exam within clinically acceptable limits.

You CAN'T join if...

  • Subject is unable to provide written informed consent or comply with the protocol.
  • Subject is younger than 18 years of age.
  • Subject has had atopic dermatitis for less than 3 years prior to enrollment.
  • Subject with mild atopic dermatitis (EASI<16 and IGA<3) or is not a candidate for phototherapy or systemic treatments.
  • Subject with current, or a history of, severe atopic dermatitis well controlled on current therapy.
  • Serious known infection.
  • History of immunosuppression (including human immunodeficiency virus (HIV))
  • History of malignancy within 5 years before the screening visit, except completely treated in situ carcinoma of the cervix, completely treated and resolved non-metastatic squamous or basal cell carcinoma of the skin.
  • Severe concomitant illnesses.
  • Having used immunosuppressive/immunomodulating drugs (eg, systemic corticosteroids,cyclosporine, mycophenolate-mofetil, IFN-γ, Janus kinase inhibitors, azathioprine,methotrexate, etc.) or phototherapy within 4 weeks before the baseline visit.
  • Treatment with topical corticosteroid or topical calcineurin inhibitor within 1 week before the baseline visit.
  • Treatment with any cell-depleting agents including but not limited to rituximab:within 6 months before the baseline visit, or until lymphocyte count returns to normal, whichever is longer, or use of other biologics: within 5 half-lives (if known)or 16 weeks prior to baseline visit, whichever is longer.
  • Physical or laboratory exam not within clinically acceptable limits.
  • Subjects possess other diagnoses that, in the investigator's opinion, preclude him/her from safely participating in this study or interfere with the evaluation of the subject's atopic dermatitis.
  • History of known or suspected intolerance to any of the ingredients of the investigational study product.
  • Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test (>10 mIU/mL).

Location

  • UCSF Psoriasis Center not yet accepting patients
    San Francisco, California, 94118, United States

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT03293030
Phase
Phase 4
Lead Scientist
Wilson Liao
Study Type
Interventional
Last Updated
September 21, 2017
I’m interested in this study!