Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Francisco, California
Dates
study started
completion around
Principal Investigator
by Miles Conrad, MD
Headshot of Miles Conrad
Miles Conrad

Description

Summary

The goal of this patient registry is to learn about the natural history in patients with chronic thromboembolic disease (CTD) and/or chronic thromboembolic pulmonary hypertension (CTEPH). The main question[s] it aims to answer are:

  • Long-term outcome after various types of treatment, including medication, balloon pulmonary angioplasty, and pulmonary endarterectomy
  • Effect of treatment on patient's quality of life and exercise tolerance Participants will be followed longitudinally to assess their health outcomes and quality of life via chart review and health quality surveys.

Official Title

Chronic Thromboembolic Disease: A Prospective Registry

Keywords

Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Disease, Pulmonary Hypertension, Thromboembolism

Eligibility

You can join if…

Open to people ages 18 years and up

  • Patients referred with CTED and/or CTEPH defined as:
    1. Mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest with pulmonary vascular resistance (PVR) > 2 Wood units (WU); or if mPAP ≤ 20 mmHg or PVR ≤ 2 WU at rest, have exercise limitations from chronic thromboembolic pulmonary disease (CTEPD) without pulmonary hypertension (PH)
    2. Radiologic finding of chronic thromboembolic disease, including abnormal ventilation perfusion scan, pulmonary angiogram, computer tomographic pulmonary angiogram, or magnetic resonance pulmonary angiogram
    3. Post-embolic exercise intolerance and evidence of chronic thromboembolic disease in the absence of resting pulmonary hypertension
  • Treatment with anticoagulation for ≥ 3 months before diagnosis of CTEPH or CTEPD without PH
  • Age ≥ 18 years

You CAN'T join if...

  • Main cause of PH other than World Health Organization (WHO) group 4 (CTEPH)
  • Patient's refusal to participate in clinical research and/or receive intervention

Location

  • UCSF accepting new patients
    San Francisco California 94143 United States

Lead Scientist at UCSF

  • Miles Conrad, MD
    Miles Conrad, MD, MPH is a Clinical Professor in the Department of Radiology at the University of California, San Francisco. In 2001, Dr. Conrad received his MD from Dartmouth Medical School in Hanover, New Hampshire, and in 2002 he obtained his MPH in Quantitative Methods from Harvard School of Public Heath in Boston.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT05843500
Study Type
Observational [Patient Registry]
Participants
Expecting 100 study participants
Last Updated