Hypoxia clinical trials at UCSF

14 in progress, 7 open to eligible people

Showing trials for

  • buRst-supprESsion TO Stop Refractory Status Epilepticus Post-cardiac Arrest

    open to eligible people ages 18 years and up

    RESTORE is a randomized clinical trial investigating the safety and feasibility of using EEG treatment targets (burst suppression vs. seizure suppression) for post-cardiac arrest refractory status epilepticus treatment.

    San Francisco, California

  • Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients

    open to eligible people ages 18 years and up

    A multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.

    San Francisco, California and other locations

  • Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)

    open to eligible people ages up to 17 years

    This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest. The study team hypothesizes that longer durations of cooling may improve either the proportion of children that attain a good neurobehavioral recovery or may result in better recovery among the proportion already categorized as having a good outcome.

    Oakland, California and other locations

  • Accuracy of the EvieMED Ring Pulse Oximeter in Profound Hypoxia

    open to eligible people ages 18-49

    The goal of this study was to evaluate the accuracy of pulse oximeters over the range of 70-100% per the International Organization for Standardization (ISO) 80601-2-61:2019. Four test devices were placed on each subject on the left or right hand with two at the finger base and two at the fingertip. Motion equipment was used to control motion of the test devices. In addition, two test devices were placed on the contralateral hand on the base of a finger and also on the fingertip. Finally, a test wrist device was placed on either the left or right wrist. SpO2 measurements from these devices were compared to sampling of arterial blood during brief stable oxygen desaturation in healthy volunteers to evaluate the claimed range.

    San Francisco, California

  • Neonatal Seizure Registry, GEnetics of Post-Neonatal Epilepsy

    open to all eligible people

    The NSR-GENE study is a longitudinal cohort study of approximately 300 parent-child trios from the Neonatal Seizure Registry and participating site outpatient clinics that aims to evaluate whether and how genes alter the risk of post-neonatal epilepsy among children with acute provoked neonatal seizures. The researchers aim to develop prediction rules to stratify neonates into low, medium, and high risk for post-neonatal epilepsy based on clinical, electroencephalogram (EEG), magnetic resonance imaging (MRI), and genetic risk factors.

    San Francisco, California and other locations

  • Pulse Oximeter Accuracy in Healthy Humans During Hypoxia

    open to eligible people ages 21-50

    The aim of this project is to test the accuracy of pulse oximeters during mild, moderate and severe hypoxia. This is done by comparing the reading of the pulse oximeter during brief, steady state hypoxia with a gold-standard measurement of blood oxygen. This study will be done on healthy male or females between the age group of 18-50.

    San Francisco, California

  • Pulse Oximetry Errors in Hospitalized Patients Across Varying Skin Pigmentation

    open to eligible people ages 18 years and up

    This is a prospective observational study designed to quantify and understand errors in pulse oximetry in hospitalized patients in relation to their skin pigmentation. It is driven by three recent retrospective studies showing missed diagnosis of hypoxemia in patients across a spectrum of skin pigmentation, defined as blood SaO2 <90% when their pulse oximeter reads 92% or greater.

    San Francisco, California

  • Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior

    Sorry, not currently recruiting here

    Determine 1) the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay (ND) outcomes and 2) how this relationship is modified by patient and environmental factors such as chronic congenital heart disease (CCHD) lesion, maternal-fetal environment, and social determinants of heath (SDOH) in a diverse population using a multicenter design. Pregnant women will be approached during one of their fetal cardiology clinic visits.

    San Francisco, California and other locations

  • TIME Study: Therapeutic Hypothermia for Infants With Mild Encephalopathy

    Sorry, not yet accepting patients

    The TIME study is a randomized, controlled trial to evaluate impact on early measures of neurodevelopment and the safety profile of therapeutic hypothermia in term neonates with Mild Hypoxic-Ischemic Encephalopathy who are < 6 hours of age. Neurodevelopmental outcome will be assessed at 12-14 months of age. The study will enroll 68 neonates randomized to therapeutic hypothermia or normothermia across 5 centers in California.

    Oakland, California and other locations

  • Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO16)

    Sorry, in progress, not accepting new patients

    The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling. Study will be used with patients at rest.

    San Francisco, California

  • Accuracy of Pulse Oximeters With Profound Hypoxia At Rest (NIHO17)

    Sorry, in progress, not accepting new patients

    The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling. Study will be used with patients at rest.

    San Francisco, California

  • Determination of SpO2 and PR Accuracy Specifications At Rest (71Ag_Vital-0031)

    Sorry, in progress, not accepting new patients

    The aim of this study is to determine the accuracy of devices called pulse oximeters, which measure blood oxygen by shining light through fingers, ears or other skin, without requiring blood sampling. Study will be used with patients at rest

    San Francisco, California

  • Neonatal Seizure Registry - Developmental Functional EValuation

    Sorry, in progress, not accepting new patients

    The NSR-DEV study is a longitudinal cohort study of around 280 Neonatal Seizure Registry participants that aims to evaluate childhood outcomes after acute symptomatic neonatal seizures, as well as examine risk factors for developmental disabilities and whether these are modified by parent well-being.

    San Francisco, California and other locations

  • Tissue-specific Insulin Resistance in Obstructive Sleep Apnea: Role of Hypoxia

    Sorry, in progress, not accepting new patients

    Obstructive sleep apnea (OSA) is a common condition associated with significant adverse health outcomes. Our overarching hypothesis is that patients with OSA and hypoxia (H-OSA) have greater degrees of insulin resistance in both liver and adipose tissue when compared to those without hypoxia (NH-OSA) thus leading to increased risk for the development of diabetes in the former group.

    San Francisco, California

Our lead scientists for Hypoxia research studies include .

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