Juvenile Idiopathic Arthritis clinical trials at UCSF

2 in progress, 1 open to eligible people

Showing trials for

  • Sequential Medications AfteR TNFi Failure in Juvenile Idiopathic Arthritis

    open to eligible people ages 2-17

    This study is an open-label, randomized, multicenter trial that incorporates a multi-arm design comparing each of 3 non-TNFi (Tumor Necrosis Factor inhibitor) medications to a second TNFi (active control) within a sequential multiple assignment randomized trial design with 2 randomization stages corresponding with clinical decision points. The first randomization addresses whether each of the 3 non-TNFi medications is superior to treatment with a second TNFi. The second randomization allows identification of optimal sequential use of biologics (treatment strategies).

    San Francisco, California and other locations

  • Adalimumab Dose Adjustment for Pediatric Uveitis Treatment Trial

    Sorry, not yet accepting patients

    The goal of this clinical trial is to learn whether children and young adults with well-controlled juvenile idiopathic arthritis (JIA)-associated uveitis or chronic anterior uveitis can safely take adalimumab (or biosimilar) injections less often while maintaining control of their disease. The main question it aims to answer is: can adalimumab/biosimilar injections be given less frequently without uveitis (eye inflammation) or arthritis (joint inflammation) returning? Researchers will compare adalimumab/biosimilar injection schedules of every 2 weeks, 4 weeks, 8 weeks, and 12 weeks to determine how injection frequency affects disease control. Participants will: - Take adalimumab/biosimilar injections every 2, 4, 8, or 12 weeks. - Attend study visits every 6 weeks over 24 weeks, with an additional follow-up visit at 48 weeks for checkups, tests, and questionnaires. - Keep a diary of how often they take adalimumab/biosimilar and other drugs they take for their uveitis/arthritis.

    San Francisco, California and other locations

Our lead scientists for Juvenile Idiopathic Arthritis research studies include .

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