Kidney Transplant clinical trials at UCSF
18 in progress, 5 open to eligible people
A kidney transplant involves getting a new kidney from a donor to replace a failing one. UCSF is conducting studies on the safety and effects of vonsetamig in kidney transplants. UCSF also examines exercise programs for transplant recipients. The APOLLO study is exploring long-term results of kidney donation and transplantation.
Learn How Safe and Tolerable Vonsetamig is in Adult Patients With Chronic Kidney Disease (CKD) Who Need Kidney Transplantation and Are Highly Sensitized to Human Leukocyte Antigen (HLA)
open to eligible people ages 18-70
The purpose of this study is to determine whether vonsetamig will safely decrease anti-HLA antibodies to allow for kidney transplantation. Vonsetamig is being studied for treatment of patients in need of kidney transplantation who are highly…
San Francisco, California and other locations
Daratumumab and Belatacept for Desensitization
open to eligible people ages 18-65
Some kidney transplant candidates have a very low chance of getting a kidney transplant because their immune systems are "highly sensitized" to most kidney donors. Being "highly sensitized" means that they will likely have to wait a long time (more…
San Francisco, California
Structured Program of Exercise for Recipients of Kidney Transplantation
open to eligible people ages 50 years and up
Older patients with end- stage kidney disease (ESKD) are at very high risk for functional impairment. Kidney transplantation (KT) has the potential to ameliorate the detrimental effects of ESKD on physical activity and functional status. However, KT …
San Francisco, California
Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
open to eligible people ages 18-70
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347). No study drug will be given…
San Francisco, California and other locations
APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)
open to all eligible people
The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a…
San Francisco, California and other locations
TCD601 in de Novo Renal Transplant Recipients
Sorry, in progress, not accepting new patients
The purpose of this study is to evaluate the safety and efficacy of TCD601 in combination with Belatacept when compared to standard of care immunosuppression therapy in de novo renal transplant patients.
San Francisco, California and other locations
TCD601 in the Induction of Tolerance in Renal Transplantation (PANORAMA)
Sorry, in progress, not accepting new patients
The purpose of this study is to determine the optimal regimen for the use of siplizumab, a human anti-CD2 antibody, combined with donor bone marrow cells and non-myeloablative conditioning, for tolerance induction in living donor renal…
San Francisco, California and other locations
BIVV020 (SAR445088) n Prevention and Treatment of Antibody-mediated Rejection (AMR)
Sorry, in progress, not accepting new patients
Primary Objectives: - Cohort A: To evaluate the efficacy of BIVV020 in prevention of AMR - Cohort B: To evaluate the efficacy of BIVV020 in treatment of active AMR Secondary Objectives: - To assess the overall efficacy of BIVV020 in prevention or…
San Francisco, California and other locations
Ravulizumab Administered Intravenously in Adult Participants at High Risk of Delayed Graft Function After Kidney Transplantation
Sorry, not currently recruiting here
The primary objective of this study is to demonstrate the efficacy of ravulizumab vs placebo in reducing the severity of DGF as measured by time to freedom from dialysis in adult participants who are at high risk of DGF after undergoing transplant…
San Francisco, California and other locations
Kidney Transplant Preemptive Therapy or Prophylaxis for CMV Prevention in D+R Recipients
Sorry, not yet accepting patients
This is a prospective, randomized multicenter trial of preemptive therapy (PET) vs. antiviral prophylaxis (AP) for prevention of cytomegalovirus (CMV) disease in adult D+R- kidney transplant recipients (KTR). Patients meeting study eligibility…
San Francisco, California and other locations
Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)
Sorry, not currently recruiting here
This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.
San Francisco, California and other locations
Preventive Human Papillomavirus (HPV) Vaccine Trial in Kidney Transplant Recipients
Sorry, in progress, not accepting new patients
This phase II trial studies whether the nonavalent human papillomavirus vaccine given to adults prior to kidney transplantation can help the body build and maintain an effective immune response during the post-transplant period when they receive…
San Francisco, California and other locations
Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx
Sorry, in progress, not accepting new patients
An open-label, controlled, randomized Phase 3 trial evaluating 12-month kidney function in highly sensitized (cPRA ≥99.9%) kidney transplant patients with positive crossmatch against a deceased donor, comparing desensitization using imlifidase with…
San Francisco, California and other locations
Tegoprubart in Patients Undergoing Kidney Transplantation
Sorry, in progress, not accepting new patients
This study will evaluate the safety and efficacy of AT-1501 compared with tacrolimus in patients undergoing kidney transplantation.
San Francisco, California and other locations
Vouchers for Improving Transplant Access to Lifestyle Nutrition - Kidney Transplant
Sorry, accepting new patients by invitation only
This study evaluates the effect of a six-month fruit and vegetable voucher program on satisfaction, dietary quality, and health outcomes among pediatric and young adult kidney transplant recipients experiencing food insecurity.
San Francisco, California
Watermelon/UBIQuinone Study
Sorry, in progress, not accepting new patients
The objective of the proposed pilot trial is to determine the feasibility and safety of increasing watermelon consumption, with or without coenzyme Q supplementation in patients after kidney transplantation on kidney function and urinary protein…
San Francisco, California
Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry
Sorry, in progress, not accepting new patients
This is an observational study to evaluate safety and efficacy outcomes in renal transplant recipients in whom post-transplant care is managed using AlloSure®. AlloSure® is a non-invasive test to measure donor-derived cell-free DNA (dd-cfDNA). The…
San Francisco, California and other locations
Predicting Mortality in Kidney Transplant Recipients
Sorry, accepting new patients by invitation only
Accurately predicting kidney recipient risk of death has a crucial interest because of the organ shortage, the need to optimize allograft allocation by identifying high-risk patients who may not benefit from a transplant and improve the clinical…
San Francisco, California and other locations
Our lead scientists for Kidney Transplant research studies include Elaine Ku Meyeon Park, MD Flavio G. Vincenti Garrett Roll, MD Eva Glenn Lecea, MD.
Last updated: