This study is not yet accepting patients

APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

a study on Kidney DiseaseKidney Transplant

Summary

at San Francisco, California and other locations
study started
estimated completion
Chi-yuan Hsu Meyeon Park

Description

Summary

The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.

Details

The National Institutes of Health (NIH)-sponsored collaborative APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is charged with prospectively assessing the effects of renal-risk variants (RRVs) in the apolipoprotein L1 gene (APOL1) on outcomes for kidneys from donors with recent African ancestry and the recipients of their kidneys, after deceased- and living-donor renal transplantation. For the purposes of APOLLO, recent African ancestry is defined as individuals with similar genetic make-up to those currently residing in Africa. APOLLO will also study the impact of APOL1 RRVs on the health of living kidney donors with recent African ancestry.

Keywords

Kidney DiseasesKidney FailureKidney Disease, ChronicApolopoprotein L1 gene (APOL1)Kidney TransplantationKidney DonorUnited Network for Organ Sharing (UNOS)Association of Organ Procurement Organizations (AOPO)Kidney Transplantation Outcomes NetworkChronic DiseaseRenal InsufficiencyRenal Insufficiency, ChronicRecipients of a Kidney TransplantLiving Kidney Donors

Eligibility

You can join if…

for Living Donors:

  • Living kidney donors with self-reported recent African ancestry (defined as African American, Afro-Caribbean, Hispanic black or African) will be eligible for inclusion.

You CAN'T join if...

for Living Donors:

  • Participants who are unable or unwilling to provide informed consent.

Inclusion Criteria for Recipients:

  • Recipients of a kidney transplant from an eligible living or deceased donor with recent African ancestry.
  • Recipients of multi-organ transplants including a kidney plus an additional organ (i.e. liver, heart, lung, pancreas, etc.) or pediatric en bloc and dual kidney transplants.

Exclusion Criteria for Recipients:

  • Participants who are unable or unwilling to provide informed consent.

Locations

  • University of California San Francisco not yet accepting patients
    San FranciscoCalifornia94143United States
  • Saint Louis University Center for Transplantation not yet accepting patients
    Saint LouisMissouri63104United States

Lead Scientists

  • Chi-yuan Hsu
    The overarching theme of Dr. Hsu's research relates to the study of patients with chronic kidney disease. Previous projects have refined understanding of causes of chronic kidney disease (such as obesity, diabetes and hypertension) and defined consequences of chronic kidney disease (such as anemia, cardiovascular disease and acute kidney injury).
  • Meyeon Park
    My research focuses on the early diagnosis of kidney hypoxia, injury, and disease and the influence of cardiovascular disease on kidney disease onset and progression. Clinically, I see patients with all manifestations of hypertension and kidney disease, with a special focus on patients with polycystic kidney disease.

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
Wake Forest University Health Sciences
ID
NCT03615235
Study Type
Observational
Last Updated