Summary

at San Francisco, California and other locations
study started
estimated completion:
Chi-yuan Hsu Meyeon Park

Description

Summary

The APOLLO study is being done in an attempt to improve outcomes after kidney transplantation and to improve the safety of living kidney donation based upon variation in the apolipoprotein L1 gene (APOL1). Genes control what is inherited from a family, such as eye color or blood type. Variation in APOL1 can cause kidney disease. African Americans, Afro-Caribbeans, Hispanic Blacks, and Africans are more likely to have the APOL1 gene variants that cause kidney disease. APOLLO will test DNA from kidney donors and recipients of kidney transplants for APOL1 to determine effects on kidney transplant-related outcomes.

Details

The National Institutes of Health (NIH)-sponsored collaborative APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) is charged with prospectively assessing the effects of renal-risk variants (RRVs) in the apolipoprotein L1 gene (APOL1) on outcomes for kidneys from donors with recent African ancestry and the recipients of their kidneys, after deceased- and living-donor renal transplantation. For the purposes of APOLLO, recent African ancestry is defined as individuals with similar genetic make-up to those currently residing in Africa. APOLLO will also study the impact of APOL1 RRVs on the health of living kidney donors with recent African ancestry.

Keywords

Kidney Diseases Kidney Failure Kidney Disease, Chronic Apolopoprotein L1 gene (APOL1) Kidney Transplantation Kidney Donor United Network for Organ Sharing (UNOS) Association of Organ Procurement Organizations (AOPO) Kidney Transplantation Outcomes Network Chronic Disease Renal Insufficiency Renal Insufficiency, Chronic Recipients of a Kidney Transplant Living Kidney Donors

Eligibility

You can join if…

for Living Donors:

  • Living kidney donors with self-reported recent African ancestry (defined as African American, Afro-Caribbean, Hispanic black or African) will be eligible for inclusion.

You CAN'T join if...

for Living Donors:

  • Participants who are unable or unwilling to provide informed consent.

Inclusion Criteria for Recipients:

  • Recipients of a kidney transplant from an eligible living or deceased donor with recent African ancestry.
  • Recipients of multi-organ transplants including a kidney plus an additional organ(i.e. liver, heart, lung, pancreas, etc.) or pediatric en bloc and dual kidney transplants.

Exclusion Criteria for Recipients:

  • Participants who are unable or unwilling to provide informed consent.

Locations

  • University of California San Francisco not yet accepting patients
    San Francisco California 94143 United States
  • Saint Louis University Center for Transplantation not yet accepting patients
    Saint Louis Missouri 63104 United States
  • University of Wisconsin - Madison not yet accepting patients
    Madison Wisconsin 53792 United States
  • Vanderbilt University Medical Center not yet accepting patients
    Nashville Tennessee 37232 United States
  • University of Alabama at Birmingham not yet accepting patients
    Birmingham Alabama 35233 United States
  • University of Michigan Medicine not yet accepting patients
    Ann Arbor Michigan 48109 United States
  • Emory University School of Medicine not yet accepting patients
    Atlanta Georgia 30322 United States
  • Cleveland Clinic not yet accepting patients
    Cleveland Ohio 44106 United States
  • Wake Forest School of Medicine not yet accepting patients
    Winston-Salem North Carolina 27157 United States
  • Duke University not yet accepting patients
    Durham North Carolina 27705 United States
  • University of Maryland School of Medicine not yet accepting patients
    Baltimore Maryland 21201 United States
  • Johns Hopkins University not yet accepting patients
    Baltimore Maryland 21205 United States
  • University of Pennsylvania not yet accepting patients
    Philadelphia Pennsylvania 19104 United States
  • University of Miami / Miami Transplant Institute not yet accepting patients
    Miami Florida 33133 United States
  • Columbia University Irving Medical Center not yet accepting patients
    New York New York 10032 United States
  • Weill Cornell Medicine not yet accepting patients
    New York New York 10065 United States
  • Ichan School of Medicine at Mount Sinai not yet accepting patients
    New York New York 10029 United States
  • Joslin Diabetes Center Harvard University not yet accepting patients
    Boston Massachusetts 02215 United States

Details

Status
not yet accepting patients
Start Date
Completion Date
(estimated)
Sponsor
Wake Forest University Health Sciences
ID
NCT03615235
Lead Scientists
Chi-yuan Hsu
Meyeon Park
Study Type
Observational
Last Updated
July 30, 2018