for people ages up to 30 years (full criteria)
at Oakland, California and other locations
study started



This research study is collecting and storing samples of bone marrow and blood from patients with relapsed acute lymphoblastic leukemia or relapsed non-Hodgkin lymphoma. Collecting and storing samples of bone marrow and blood from patients with cancer to study in the laboratory may help doctors learn more about cancer and help predict the recurrence of cancer.

Official Title

A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens



  1. Establish a mechanism to bank specimens of tumor cells and host germline DNA from patients with acute lymphoblastic leukemia (ALL) at first and subsequent relapse.

II. Make these specimens available to qualified researchers to study the biology of ALL.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and peripheral blood at diagnosis of relapse and/or at the end of the first month of treatment.

Patients are followed periodically for up to 10 years.


Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Non-Hodgkin Lymphoma Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Non-Hodgkin Lymphoma Lymphoma Leukemia Lymphoma, Non-Hodgkin Precursor Cell Lymphoblastic Leukemia-Lymphoma Leukemia, Lymphoid Cytology Specimen Collection Procedure Laboratory Biomarker Analysis Ancillary-Correlative (Collecting and banking ALL specimens)


For people ages up to 30 years

Inclusion Criteria:

  • Diagnosis of acute lymphoblastic leukemia (ALL) or prior history of non-Hodgkin lymphoma
  • In first or subsequent marrow relapse with ? 25% blasts in bone marrow and/or peripheral blood
  • Bone marrow and/or peripheral blood samples (? 5 mL) required at the time of diagnosis of relapse
  • No concurrent systemic antileukemic treatment administered for current relapse
  • Intrathecal chemotherapy allowed
  • On-therapy relapse allowed


  • Children's Hospital and Research Center at Oakland
    Oakland California 94609-1809 United States
  • UCSF Medical Center-Parnassus
    San Francisco California 94143 United States
  • UCSF Medical Center-Mission Bay
    San Francisco California 94158 United States


in progress, not accepting new patients
Start Date
Children's Oncology Group
Study Type
Last Updated