for people ages 18 years and up (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Kathleen Liu



The primary objective is to safely determine if the investigators can identify the severity of Acute Kidney Injury (AKI) early in the course of the disease. Once enrolled the investigators will draw blood and urine for novel and standard biomarkers. The investigators are attempting to determine if these biomarkers can forecast the course of AKI (need for dialysis, death and renal recovery). The investigators seek to determine how well physicians caring for those with AKI can predict the clinical course compared to these novel biomarkers of AKI and if there is an association between clinical course and 3 year patient outcomes.


AKI is a very common disease in the setting of critical illness and carries an extremely high morbidity and mortality rate (over 50%). Currently there are no FDA approved therapuetic agents for the treatment of AKI. There is limited prospective evidence to guide nephrologists in terms of which patients will progress to more severe AKI in the setting of early AKI. Similarly, there is no evidence to guide nephrologists in terms of which patients will completely recover their renal function after AKI. Thus we need to know very early in the course of AKI which patients will progress and go on to require RRT. Additonally we will investigating the long term patient outcomes, 2-3 years after the index AKI admission.


Acute Kidney FailureRenal Replacement TherapyDiureticsBiomarkersRenal InsufficiencyFurosemideTherapeutic UsesPhysiological Effects of DrugsBiological MarkersAcute Kidney InjurySodium Potassium Chloride Symporter InhibitorsLasix


You can join if…

Open to people ages 18 years and up

  1. 18 yrs or older
  2. increase in serum creatinine of 0.3 mg/dl within 48 hours or an increase of greater than or equal to 150% from baselinie or sustained oliguria (UOP < 0.5 cc/kg/hr for 6 hours with the last 48hours)
  3. written informed consent
  4. patients with an indwelling bladder catheter

You CAN'T join if...

  1. Voluntary refusal
  2. Patients with advanced chronic kideny disease - as defined by a baseline GFR < 30 ml/min (MDRD)
  3. history of renal transplant
  4. Pregnant patients
  5. Allegery / Sensitivity to Loop diuretics (furosemide)
  6. Pre-renal AKI
  7. defined by a FENa of < 1% and no urinary casts
  8. under-resuscitatedas per the treating clinical team
  9. active bleed
  10. Post renal AKI
  11. evidence of hydro-ureter
  12. clincal scenario wherein obstruction is considered a likely possibility


  • University of California-San Franciscoaccepting new patients
    San FranciscoCalifornia94143United States
  • University of Chicagoaccepting new patients
    ChicagoIllinois60637United States

Lead Scientist

  • Kathleen Liu
    EDUCATION College: Harvard University, AB Medical/Graduate School: University of California, San Francisco, MD, PhD RESEARCH My current research areas of interest focus on the predictive and pathogenetic role of biomarkers for both acute and chronic disease states.


accepting new patients
Start Date
Completion Date
University of Chicago
Study Type
Last Updated