Cardiovascular Disease clinical trials at UCSF
17 in progress, 9 open to eligible people
Cholesterol and Inflammation Lowering Via Bempedoic Acid, an ACL-inhibiting Regimen in HIV Trial (CLEAR HIV Trial)
open to eligible people ages 40 years and up
This is a randomized placebo-controlled study in treated and suppressed HIV-infected individuals aged ≥40 years with either known CVD or 1 CVD risk factor to study the effect of Bempedoic acid (BA) on safety, arterial inflammation as assessed by…
San Francisco, California
PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study)
open to eligible people ages 40 years and up
Atherosclerosis in the setting of HIV infection is distinct and includes increased vascular inflammation, worsened endothelial function, and a predominance of non-calcified plaque. These outcomes can be assessed using specialized noninvasive imaging …
San Francisco, California
Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC)
open to eligible people ages 21-70
This is a crossover study that will examine use behaviors, chemical exposures, and biological effects of Standardized Research Electronic Cigarette (SREC) compared to usual brand e-cigarette use in natural or synthetic nicotine users.
San Francisco, California
Secondhand Tobacco Smoke and Cardiovascular Disease
open to eligible people ages 40 years and up
This is a double-blind randomized placebo-controlled crossover clinical trial of efficacy and safety of an FDA-approved angiotensin receptor blocker (losartan) to improve cardiopulmonary outcomes in individuals with pre-Chronic Obstructive Pulmonary …
San Francisco, California
SPYRAL AFFIRM Global Study of RDN With the Symplicity Spyral RDN System in Subjects With Uncontrolled HTN
open to eligible people ages 18 years and up
The purpose of this single-arm interventional study is to evaluate the long-term safety, efficacy, and durability of the Symplicity Spyral system in subjects treated with renal denervation. Additionally, long-term follow-up data will also be…
San Francisco, California and other locations
Text Education About Cardiovascular Health and HIV (TEACH-HIV)
open to eligible people ages 40 years and up
The overall objective is to evaluate the efficacy of educational text messages to reduce cardiovascular risk among persons living with HIV (PLWH).
San Francisco, California and other locations
EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With at Least Mild FMR
open to eligible people ages 18 years and up
The objective of this prospective, randomized, blinded clinical trial is to assess the safety and efficacy of the Carillon Mitral Contour System in treating heart failure with functional regurgitation (FMR).
San Francisco, California and other locations
VictORION-INCLUSION: Evaluating Inclisiran for Cholesterol Managment in Heart Disease
open to eligible people ages 18 years and up
VictORION-INCLUSION (V-INCLUSION) seeks to evaluate the effectiveness of inclisiran as an innovative therapy with the potential to help bridge care gaps in historically understudied and undertreated populations by leveraging electronic health…
San Francisco, California and other locations
Virtual Care Strategies to Improve Participation in Cardiac Rehabilitation Among Veterans
open to eligible people ages 21 years and up
Home-based CR (HBCR) is an alternative to traditional CR programs that has comparable efficacy in improving morbidity/mortality and increases access to critical services. There is major potential to improve Veteran engagement in CR by combining…
San Francisco, California and other locations
Patient Care Outreach, Navigation, Technology and Support 2.0
Sorry, currently not accepting new patients, but might later
This is a feasibility study employing virtual patient navigation for underserved individuals who speak English, Chinese or Spanish and were diagnosed with breast cancer or cardiovascular disease to determine the extent of usability for a virtual…
San Francisco, California and other locations
Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With CVD
Sorry, in progress, not accepting new patients
This is a pivotal phase 3 study designed to support an indication for the reduction of cardiovascular risk in patients with established CVD and elevated Lp(a)
San Francisco, California and other locations
SCULPT-Job Cohort Study
Sorry, in progress, not accepting new patients
This is an research study about clinical, psychosocial, and behavioral factors that impact weight loss, weight maintenance, and cardiovascular disease in socially disadvantaged persons.
San Francisco, California
TRISCEND II Pivotal Trial
Sorry, in progress, not accepting new patients
Pivotal trial to evaluate the safety and effectiveness of the Edwards EVOQUE tricuspid valve replacement system
San Francisco, California and other locations
Health eHeart BioBank
Sorry, accepting new patients by invitation only
The purpose of the Health eHeart BioBank is to collect and store specimen (e.g. blood, DNA, tissue) for future studies at the University of California, San Francisco (UCSF) that will help determine changes and identify molecular and genetic markers…
San Francisco, California
Innovative Support for Patients with SARS-COV2 Infections (COVID-19) Registry (INSPIRE)
Sorry, in progress, not accepting new patients
The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have suspected COVID…
San Francisco, California and other locations
Mediators of Atherosclerosis in South Asians Living in America
Sorry, not currently recruiting here
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the…
San Francisco, California and other locations
Ovarian Aging and Cardiovascular Risk
Sorry, accepting new patients by invitation only
Despite significant improvements in prevention and treatment of cardiovascular disease (CVD), the growing aging population suggests CVD will continue to pose a significant public health burden. Women are a special group where microvascular disease…
San Francisco, California
Our lead scientists for Cardiovascular Disease research studies include Neal Benowitz Mehrdad Arjomandi Priscilla Hsue, MD James P Pirruccello, MD Vasanth Vedantham, MD Megan McLaughlin Marcelle I Cedars, MD John Chorba, MD Alka Kanaya, MD Richard Cheng, MD Scarlett L Gomez, PhD Sammy Elmariah, MD, MPH Gregory Marcus, MD Jeffrey E Olgin, MD Linda Grace Park, PhD MS NP.
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