for people ages 22-75 (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Principal Investigator
by Jill Ostrem
Headshot of Jill Ostrem
Jill Ostrem



The purpose of this study is to evaluate the safety and effectiveness of Boston Scientific's Vercise Deep Brain Stimulation (DBS) system in the treatment of patients with with advanced, levodopa-responsive bilateral Parkinson's disease (PD) which is not adequately controlled with medication.

Official Title

Implantable Neurostimulator for the Treatment of Parkinson's Disease


The study is multi-center, prospective, double-blind, randomized (3:1) controlled trial. GUIDE XT may be used for planning of programming as needed.


Parkinson's Disease Intrepid, Vercise, PD, DBS, Boston Scientific Parkinson Disease Deep Brain Stimulation


You can join if…

Open to people ages 22-75

  • Diagnosis of bilateral idiopathic PD (H&Y ≥ 2) with a duration of PD ≥ 5 years.
  • Persistent disabling Parkinson's disease symptoms or drug side effects (e.g., dyskinesias, motor fluctuations, or disabling "off" periods) despite optimal medical therapy.
  • Able to understand the study requirements and the treatment procedures and provides written informed consent before any study-specific tests or procedures are performed.

You CAN'T join if...

  • Any intracranial abnormality or medical condition that would contraindicate DBS surgery.
  • Have any significant psychiatric condition likely to compromise the subject's ability to comply with requirements of the study protocol
  • Any other active implanted devices including neurostimulators and /or drug delivery pumps
  • Any previous thalamotomy, pallidotomy or subjects who have undergone a DBS procedure.
  • Have any significant medical condition that is likely to interfere with study procedures or likely to confound evaluation of study endpoints.
  • A female who is breastfeeding or of child-bearing potential with a positive urine pregnancy test or not using adequate contraception.


  • University of California, San Francisco
    San Francisco California 94115 United States
  • Kaiser Permanente, Sacramento
    Sacramento California 95825 United States

Lead Scientist at UCSF

  • Jill Ostrem
    Professor, Neurology. Authored (or co-authored) 147 research publications.


in progress, not accepting new patients
Start Date
Completion Date
Boston Scientific Corporation
Study Type
Last Updated