Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Francisco, California
Dates
study started
completion around
Principal Investigator
by Simon J Little, MBBS, PhD
Headshot of Simon J Little
Simon J Little

Description

Summary

The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.

Details

Participants will perform reward-based decision-making tasks designed to assess both self-benefitting and prosocial motivation. The tasks will evaluate how effort and reward influence decision-making, as well as how proximity to a deadline impacts choices. These tasks will be conducted in both clinic and home settings.

Throughout the study, participants will remain on their regular dopaminergic medications. Each participant will complete sessions under two stimulation conditions: their usual DBS settings and with DBS turned off. Neural activity will be recorded using the Percept device, which enables real-time and chronic at-home data streaming. Additionally, participants will wear a device that captures movement, sleep, heart rate variability, and self-reported measures.

The primary outcomes are behavioral: changes in reaction time, acceptance rate, and success rate across different DBS conditions. The secondary outcomes focus on identifying neural oscillatory biomarkers time-locked to specific decision-making events. By linking brain activity to motivational behavior, this study aims to advance our understanding of non-motor symptoms in PD and inform the development of adaptive DBS algorithms targeting these symptoms.

Keywords

Parkinson Disease, Deep Brain Stimulation, Motivation, Parkinson's, Medtronic, Percept, DBS, Parkinson's Disease, PD, Reward-based decision making, Task, Stimulation on, Stimulation off, Decision Making Task, Stimulation

Eligibility

You can join if…

Open to people ages 18 years and up

  • Has Parkinson's Disease or Dystonia
  • Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN
  • Has DBS device implanted either bilaterally or unilaterally
  • Male or female
  • More than 1 month post-DBS surgery

You CAN'T join if...

Location

  • UCSF accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Simon J Little, MBBS, PhD
    Dr. Simon Little is a neurologist who specializes in caring for patients with movement disorders, including Parkinson's disease, tremor and dystonia (involuntary muscle contractions that can cause repetitive movements and abnormal posture).

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT05065151
Study Type
Interventional
Participants
Expecting 70 study participants
Last Updated