for females ages 21 years and up (full criteria)
healthy people welcome
at San Francisco, California and other locations
study started
estimated completion
Vanessa Jacoby



The ULTRA Registry is a nationwide observational arm of the ULTRA trial. Data from the ULTRA Registry will be used to evaluate the long-term safety and efficacy of laparoscopic RF ablation (Acessa). The ULTRA Registry will recruit women age 21 or older who plan to undergo or have undergone laparoscopic RF ablation (Acessa) within the United States. Participants will be recruited through study materials distributed at clinical offices across the country where gynecologists are performing laparoscopic RF ablation (Acessa). Study participants will consent to participate in a 3 year prospective study conducted by UCSF but the laparoscopic RF ablation (Acessa) surgery will be performed by the study participants' own gynecologist. We will evaluate changes in fibroid-related symptoms from pre-treatment values to 6, 12, 18, 24, 30, and 36 months after RFA (Acessa). We will determine long-term efficacy of RFA (Acessa) by evaluating the rate of re-treatment for symptomatic fibroids after the RFA (Acessa) procedure. Participants will be asked for permission to review their medical records to assess surgical and pregnancy outcomes. The gynecologists performing the laparoscopic RF ablation (Acessa) surgery will be asked to consent to complete a brief study questionnaire with information on demographics, work history, professional training, and practice setting. UC San Francisco will have oversight of all scientific and administrative aspects of the study. All study data will be stored securely in a HIPAA compliant, secure database monitored by the UC San Francisco Coordinating Center.


Uterine FibroidsFibroidsRadiofrequency ablationLeiomyomaMyofibromaRadiofrequency ablation of fibroidsWomen undergoing radiofrequency ablation.


You can join if…

Open to females ages 21 years and up

  • Planning to undergo or have undergone RF ablation (Acessa) for treatment of uterine fibroids.*
  • Able to give informed consent
  • Women enrolled at contract clinical sites must enroll prior to their RF ablation treatment

You CAN'T join if...

  • <21 years of age


  • University of California, San Franciscoin progress, not accepting new patients
    San FranciscoCalifornia94115United States
  • MacArthur Medical Centeraccepting new patients
    IrvingTexas75062United States

Lead Scientist

  • Vanessa Jacoby
    Dr. Vanessa Jacoby is an obstetrician gynecologist with a research program focused on surgical gynecology. She has studied long-term health outcomes of hysterectomy and oophorectomy. She is the principal investigator of prospective cohort study of women with BRCA1 or BRCA2 mutations who undergo risk-reducing salpingo-oophorectomy funded by the American Cancer Society.


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Last Updated