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for females ages 18–45 (full criteria)
healthy people welcome
at San Francisco, California
study started
estimated completion:



The purpose of this study is to understand how the opioid system is involved in eating behavior.


Obesity is associated with greater risk for cardiovascular disease (CVD), stroke, diabetes, and mortality, and is a heterogeneous condition with various causes and thus a diversity of intervention targets. Compulsive overeating afflicts 30% of people seeking obesity treatment and increases risk for CVD factors. This trial involves two participant visits to test whether opioid blockade (Day 1 or 2, depending on randomization), compared to placebo (Day 1 or 2, depending on randomization), will elicit common symptoms of opioid withdrawal, including nausea. Participants will receive each condition on separate days.


Obesity Binge eating Naloxone


You can join if…

Open to females ages 18–45

  • Obese, as defined by BMI greater than or equal to 30
  • Self-reported binge eating as defined in DSM-5, in the last 4 weeks
  • If sexually active with men, must agree to use birth control until the final study visit is complete (e.g., barrier methods, oral contraceptive)
  • Subject must be able to complete written informed consent procedures and be able to comply with the requirements of the study.

You CAN'T join if...

  • Pregnant or breastfeeding
  • Severe hypotension (< 90/60 mmHg)
  • Recent or current use of vasoconstrictor or vasodilator medication
  • Current or history of diabetes
  • Allergies to any ingredients in naloxone hydrochloride
  • History of or current alcoholism or drug dependence
  • Bulimia Nervosa as defined in DSM 5
  • Current or past use of opiate-containing medications in the last 30 days
  • Plan to use opiate-containing medications during study participation period
  • Medical conditions that are contraindicated with intranasal procedures: Nasal septal abnormalities, nasal trauma, epistaxis, excessive nasal mucus, and intranasal damage caused by the use of substances (e.g., cocaine)
  • Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the subject or the quality of the data


  • University of California San Francisco accepting new patients
    San Francisco, California, 94143, United States


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Click here for more information about this study: the Biology and Experiences of Eating
Phase 2
Lead Scientist
Ashley Mason
Study Type
Last Updated
October 25, 2017
I’m interested in this study!