Post-Traumatic Stress Disorder clinical trials at UCSF
12 in progress, 6 open to eligible people
Effectiveness Study of PTSD Treatments Among Sexual and Gender Minority Populations
open to eligible people ages 18 years and up
The goal of this clinical trial is see if Cognitive Processing Therapy and STAIR Narrative Therapy work to treat posttraumatic stress disorder (PTSD) among lesbian, gay, bisexual, transgender, queer/questioning, intersex, asexual/aromantic, and all…
San Francisco, California
BLOOM: Boldly Living outdOOrs for Mental Health
open to eligible people ages 9-12
In 2019, the Office of the California Surgeon General launched the ACEs Aware Initiative in collaboration with the California Department of Health Care Services. This ambitious campaign aims to develop a network of care model of healthcare delivery…
Oakland, California
Brief Behavioral Treatment for Insomnia in Veterans With Posttraumatic Stress Disorder
open to eligible people ages 18-75
This study will investigate treatments for insomnia in Veterans who have posttraumatic stress disorder (PTSD). The purpose of this study is to compare a brief behavioral treatment for insomnia (BBTI) to a treatment that helps promote relaxation…
San Francisco, California
Selective Glucocorticoid Receptor Antagonist in the Treatment of Veterans With Posttraumatic Stress Disorder (PTSD) (Seven Study)
open to eligible people ages 18-69
The purpose of this study is to test the drug CORT108297, which blocks the hormone cortisol, for treatment of PTSD in Veterans, and establish a safety profile that will inform the design of future studies.
San Francisco, California and other locations
Modification of Attention Bias Remotely After Trauma
open to eligible people ages 18-65
The investigators will complete an entirely remote randomized controlled trial (RCT) comparing 14 sessions of attention bias modification (ABM), attention control training (ACT), placebo neutral attention training, and a final control condition with …
San Francisco, California
Suvorexant: A Dual Orexin Receptor Antagonist for Treating Sleep Disturbance in Posttraumatic Stress
open to eligible people ages 18-75
Post-traumatic stress disorder (PTSD) is a common consequence of combat that can result in trauma-related hyperarousal and sleep disturbances. Poor sleep, one of the most common complaints in Veterans with PTSD, can be distressing, impair…
San Francisco, California and other locations
Doxazosin for Nightmares, Sleep Disturbance, and Non-Nightmare Clinical Symptoms in PTSD
Sorry, in progress, not accepting new patients
This randomized, double-blind, placebo-controlled trial of doxazosin will assess doxazosin's effectiveness for PTSD nightmares, subjective sleep quality, and non-nightmare PTSD symptoms in adult men and women veterans with full and partial-syndromal …
San Francisco, California
Transdiagnostic Sleep Health Intervention for Veterans With PTSD
Sorry, not yet accepting patients
Sleep disturbance is a major problem in Veterans with posttraumatic stress disorder (PTSD). This study will test a version of a sleep treatment that's been shown to be effective in the general population, with some changes to tailor it to the needs…
San Francisco, California
Facilitating Transition to Recommended PTSD Treatment
Sorry, not yet accepting patients
Cognitive processing therapy (CPT) and prolonged exposure therapy (PE) were widely disseminated as recommended posttraumatic stress disorder (PTSD) treatments. However, post-9/11 Veterans with PTSD rarely initiate CPT or PE, especially as an initial …
San Francisco, California
Inflammatory Challenge and Fear
Sorry, not yet accepting patients
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear. The main questions it aims to answer are: Do people who receive typhoid vaccine respond differently than those who…
San Francisco, California
Oxytocin to Treat PTSD
Sorry, in progress, not accepting new patients
Posttraumatic stress disorder (PTSD) is a chronic, debilitating condition that disproportionately affects Veterans. Prolonged Exposure (PE) therapy is a "gold standard" treatment for PTSD. However, approximately one-third of Veterans fail to receive …
San Francisco, California and other locations
Orexin Antagonism on Fear Extinction in PTSD
Sorry, not yet accepting patients
PTSD affects approximately 22% of Veterans who have served in Iraq and Afghanistan. Symptoms of PTSD may include re-experiencing, avoidance of trauma reminders, negative thoughts or feelings, and hyperarousal, such as increased startle reactivity…
San Francisco, California and other locations
Our lead scientists for Post-Traumatic Stress Disorder research studies include Thomas C. Neylan, MD Sabra S Inslicht, PhD Joshua Woolley, MD, PhD Joaquin Anguera, PhD Nooshin Razani, MD MPH Nicholas Holder, PhD Shira Maguen, PhD.
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