for people ages 18-80 (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Karunesh Ganguly, MD, PhD
Headshot of Karunesh Ganguly
Karunesh Ganguly



The purpose of this study is to find out what are the best settings for applying electrical nerve stimulation over the skin for the short-term improvement of hand dysfunction after a stroke. The ultimate goal is to some day design an effective long-term training program to help someone recovery their ability to use their hands and function independently at home and in society. In order to know how to apply electrical nerve stimulation to produce a good long-term effect on hand dysfunction, we first need to know how to make it work best in the short-term, and improve our understanding of for whom it works and how it works.We will use a commercially available transcutaneous electrical nerve stimulation (TENS) unit to gently apply electrical nerve stimulation over the skin of the affected arm. This is a portable, safe and easy to use device designed for patients to operate in their homes.

Official Title

Optimizing Peripheral Stimulation Parameters to Modulate the Sensorimotor Cortex for Post-stroke Motor Recovery.


Upper Extremity Paresis, Disability Physical, Chronic Stroke, Motor Disorders, Stroke, Paresis, Somatosensory Electrical Stimulation


You can join if…

Open to people ages 18-80

- Age 18-80 years, has residual hand motor dysfunction caused by a single ischemic and/or hemorrhagic stroke greater than 6 months prior to enrollment.

You CAN'T join if...

  • Pregnant; uncontrolled medical problems including but not limited to severe cardiovascular and cardiopulmonary disease; active cancer; significant hand joint deformity or other diagnosis with major effect on hand function besides stroke; severe alcohol or drug abuse within the past year; untreated or inadequately treated major depression; spasticity score >3 on the MAS; lack of finger range of motion of at least 10 degrees; severe aphasia or other communicative, behavioral or cognitive impairment that significantly interferes with the participant's ability to comply with the protocol or provide informed consent. In addition, patients will be excluded if they have a pacemaker.


  • UCSF
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Karunesh Ganguly, MD, PhD
    Dr. Karunesh Ganguly is a neurologist who specializes in neurological rehabilitation, particularly for patients with gait or walking disorders. He also treats chronic neurological impairments following stroke or another brain injury. In his research, Ganguly studies new treatments for patients recovering from neurological conditions and injuries.


in progress, not accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 25 study participants
Last Updated