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Stroke clinical trials at UCSF
12 in progress, 8 open to eligible people

  • AMPLATZER PFO Occluder Post Approval Study

    open to eligible people ages 18-60

    The purpose of this single arm, multi-center study is to confirm the safety and effectiveness of the AMPLATZER™ PFO Occluder in the post Approval Setting.

    San Francisco, California and other locations

  • AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke

    open to eligible people ages 45 years and up

    Objectives - Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy. - Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

    Fresno, California and other locations

  • ECoG BMI for Motor and Speech Control

    open to eligible people ages 21 years and up

    Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

    San Francisco, California

  • Efficacy of Bromocriptine For Fever Reduction in Acute Neurologic Injury

    open to eligible people ages 18-100

    The purpose of this study is to evaluate the antipyretic effect of bromocriptine in critically-ill patients with acute neurologic injury and fever from infectious and non-infectious etiologies.

    San Francisco, California and other locations

  • GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study

    open to eligible people ages 18-70

    This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a post-market setting.

    San Francisco, California and other locations

  • Head Pulse for Ischemic Stroke Detection

    open to eligible people ages 18 years and up

    Accurate diagnosis of stroke due to large vessel occlusion (LVO) is an essential step in providing acute stroke care to a community. The gold-standard for diagnosis LVO is brain imaging, which is impractical in the pre-hospital setting. A non-invasive method to detect LVO is needed. Using highly sensitive accelerometers, one can measure the "HeadPulse"- tiny forces exerted on the skull from the cardiac contraction. This study tests the hypothesis that LVO alters the HeadPulse characteristically. Analysis of these data along with the subjects vascular status (LVO vs. non-LVO as measured by CT angiography) will be used to create a model that can predict LVO status in suspect stroke subjects.

    San Francisco, California

  • Ischemia Care Biomarkers of Acute Stroke Etiology (BASE)

    open to eligible people ages 18 years and up

    The proposed study will validate the clinical use of new biomarker blood tests to identify blood components that may differentiate between diverse stroke etiologies and clinical outcomes as listed below: 1. Differentiate between cardioembolic and large artery atherosclerotic ischemic strokes, when hemorrhagic stroke is ruled out. 2. In cases of ischemic strokes of unknown or "cryptogenic" etiology, determine the ability of biomarker blood tests to predict etiology between cardioembolic and large artery atherosclerotic. 3. In cases of cardioembolic ischemic stroke, further differentiation of cardioembolic ischemic strokes into those caused by atrial fibrillation (AF) and those not caused by AF. 4. Differentiate "transient ischemic attacks" (TIAs) from acute ischemic strokes. 5. Differentiate TIAs from non-ischemic "transient neurological events" (TNE) with similar symptoms.

    San Francisco, California and other locations

  • Stroke Recovery Initiative - Registry for Stroke Research Studies

    open to eligible people ages 18 years and up

    The Stroke Recovery Initiative is a nation-wide participant recruitment registry that connects people who have had a stroke with researchers who are working to develop new approaches to improve recovery after stroke.

    San Francisco, California

  • AntiCoagulation Tracking InterVention and Evaluation

    Sorry, not yet accepting patients

    The overarching goal of this project is to assess the impact and cost-effectiveness of system-level and patient-facing interventions on anticoagulation treatment and characterize the current state of safety for Direct Oral Anticoagulants (DOACs). The investigators focus on examining implementation factors and cost-effectiveness, which are critical to helping health care decision-makers prioritize finite resources, particularly in safety-net health systems where a disproportionate number of Agency for Healthcare Research and Quality's Priority Populations—low-income and racial/ ethnic minority groups—receive care. Therefore, the investigators propose to implement an Health Information Technology (HIT) population management tool with patient-facing outreach and team-based workflow, the AntiCoagulation Tracking InterVention and Evaluation (ACTIVE), and examine its effect on anticoagulation management outcomes in two diverse settings - a safety net hospital and a large academic medical center - hypothesizing that such interventions can be cost-effective strategies to improve patient safety.

  • Infliximab Therapy for Dolichoectactic Vertebrobasilar Aneurysms

    Sorry, not yet accepting patients

    Patients harboring dolichoectactic vertebrobasilar (DVB) aneurysms are at risk of suffering SAH, ischemic stroke, and/or brainstem compression and many patients are not offered invasive treatment due to the futility of existing surgical methods. Consequently, there is demand for development of medical therapy for DVB aneurysms

  • Rate of Atrial Fibrillation Through 12 Months in Patients With Recent Ischemic Stroke of Presumed Known Origin

    Sorry, in progress, not accepting new patients

    The purpose of the Stroke AF study is to compare the incidence of atrial fibrillation (AF) through 12 months between continuous cardiac rhythm monitoring with the Reveal LINQ™ Insertable Cardiac Monitor (ICM) (continuous monitoring arm) and standard of care (SoC) medical treatment (control arm) in subjects with a recent ischemic stroke of presumed known origin.

    San Francisco, California and other locations

  • Sleep for Stroke Management and Recovery Trial

    Sorry, not currently recruiting here

    The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.

    Fresno, California and other locations

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