for people ages 21 years and up (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Karunesh Ganguly, MD, PhD
Headshot of Karunesh Ganguly
Karunesh Ganguly



Test the feasibility of using electrocorticography (ECoG) signals to control complex devices for motor and speech control in adults severely affected by neurological disorders.

Official Title

A High-Performance ECoG-based Neural Interface for Communication and Neuroprosthetic Control


ECoG is a type of electrophysiological monitoring that uses electrodes placed directly on the exposed surface of the brain to record electrical activity. With this ECoG-based neural interface, study patients will undergo training and assessment of their ability to control a complex robotic system and to determine if ECoG brain signals can be used to produce speech.


ALS, SCI - Spinal Cord Injury, Stroke, Multiple Sclerosis, Muscular Dystrophies, Spinal Cord Injuries, PMT/Blackrock Combination Device, Electrocorticography-based brain computer interface


You can join if…

Open to people ages 21 years and up

  1. Age > 21
  2. Limited ability to use upper limbs, based on neurological examination, due to stroke, amyotrophic lateral sclerosis (ALS), multiple sclerosis, cervical spinal cord injury, brainstem stroke, muscular dystrophy, myopathy or severe neuropathy.
  3. Disability, defined by a 4 or greater score on the Modified Rankin Scale, must be severe enough to cause loss of independence and inability to perform activities of daily living.
  4. If stroke or spinal cord injury, at least 1 year has passed since onset of symptoms
  5. Must live within a two-hour drive of UCSF

You CAN'T join if...

  1. Pregnancy or breastfeeding
  2. Inability to understand and/or read English
  3. Inability to give consent
  4. Dementia, based on history, physical exam, and MMSE
  5. Active depression (BDI > 20) or other psychiatric illness (active general anxiety disorder, schizophrenia, bipolar disorder, obsessive-compulsive disorder (OCD), or personality disorders (e.g. multiple personality disorder, borderline personality disorder, etc.)
  6. History of suicide attempt or suicidal ideation
  7. History of substance abuse
  8. Co-morbidities including ongoing anticoagulation, uncontrolled hypertension, cancer, or major organ system failure
  9. Inability to comply with study follow-up visits

    10. Any prior intracranial surgery 11. History of seizures 12. Immunocompromised 13. Has an active infection 14. Has a CSF drainage system or an active CSF leak 15. Requires diathermy, electroconvulsive therapy (ECT), or transcranial magnetic

    stimulation (TMS) to treat a chronic condition

    16. Has an implanted electronic device such as a neurostimulator, cardiac

    pacemaker/defibrillator or medication pump, or presence of any head or neck metallic foreign bodies

    17. Allergies or known hypersensitivity to materials in the Blackrock NeuroPort Array

    (i.e. silicone, titanium) or the PMT Subdural Cortical Electrode (silicone, platinum iridium, nichrome)


  • UCSF accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Karunesh Ganguly, MD, PhD
    Dr. Karunesh Ganguly is a neurologist who specializes in neurological rehabilitation, particularly for patients with gait or walking disorders. He also treats chronic neurological impairments following stroke or another brain injury. In his research, Ganguly studies new treatments for patients recovering from neurological conditions and injuries.


accepting new patients
Start Date
Completion Date
Karunesh Ganguly
Study Type
Expecting 3 study participants
Last Updated