for people ages 18-65 (full criteria)
at San Francisco, California and other locations
study started
estimated completion
Bruce Cree



The purpose of this study is to evaluate the safety and efficacy of elezanumab in subjects with progressive Multiple Sclerosis (PMS).

Official Title

A Randomized, Double-Blind, Placebo-Controlled, Multiple Dose Study to Assess the Safety and Efficacy of Elezanumab When Added to Standard of Care in Progressive Forms of Multiple Sclerosis


Multiple Sclerosis (MS) Progressive multiple sclerosis Multiple Sclerosis Sclerosis elezanumab Elezanumab Dose 1 Elezanumab Dose 2


You can join if…

Open to people ages 18-65

  • Subject has diagnosis of primary-progressive multiple sclerosis (PPMS) or non-relapsing secondary-progressive multiple sclerosis (SPMS) and no relapses for at least 24 months
  • Subject has evidence of physical disability according to Expanded Disability Status Scale (EDSS) or Timed 25-Foot Walk (T25FW) or 9-Hole Peg Test

You CAN'T join if...

  • Treatment with any of the following within the 6 months prior to Screening: natalizumab; cyclosporine; azathioprine; methotrexate; mycophenolate mofetil; intravenous immunoglobulin (IVIg); any interferon product; and intravenous (IV), oral, or intrathecal corticosteroids for the purposes of disease modification
  • Treatment with the following within 1 year prior to Screening: cyclophosphamide or alemtuzumab


  • UCSF School of Medicine - Neurology /ID# 203194 accepting new patients
    San Francisco California 94143-0003 United States
  • Sutter East Bay Medical Foundation-Jordon Research and Education Dev. Inst. /ID# 202448 accepting new patients
    Berkeley California 94705-2017 United States

Lead Scientist

  • Bruce Cree
    Bruce Cree, MD, PhD, MAS is a Professor of Clinical Neurology and is the George A. Zimmermann Endowed Professor in Multiple Sclerosis in the Department of Neurology at the University of California San Francisco. Dr. Cree completed his MD and PhD in Biochemistry at UCSF. His neurology residency training was at Columbia University.


accepting new patients
Start Date
Completion Date
Phase 2
Study Type
Last Updated