for people ages 18-80 (full criteria)
at San Francisco, California
study started
completion around
Principal Investigator
by Riley Bove, MD
Headshot of Riley Bove
Riley Bove



The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits. MS CATCH is a smartphone-based tool which allows patients to enter their mood related symptoms at regular intervals, which is then available to their Neurologist in their electronic medical record. The neurologist is also able to view additional information from their medical record, and receives alerts for changes reported by the patient that raise concern for the patient's mental health.

Official Title

Care Technology to Ascertain, Treat, and Engage the Community to Heal Depression in Patients With Multiple Sclerosis: Closing the Gaps in Depression Care for People With MS By Closing the Information Loop


MS-CATCH (Care technology to Ascertain, Treat, and engage the Community to Heal depression in patients with Multiple Sclerosis) is a behaviorally informed, digital health, closed-loop-intervention that brings longitudinal mood reporting into the point of care. It consists of a simple tool used by the patient to improve mood reporting. This then triggers real-time alerts delivered to the clinician, who can access a comprehensive dashboard featuring risk factors and interventions to be considered, as well as resources local to the patient. This dashboard launches straight from the patient's electronic health record (EHR). MS-CATCH was designed using extensive human-centered design in all phases of development, and HIPAA compliant REDCap for electronic data capture. While the tool requires institutional approvals to launch within the UCSF EHR, the design elements could be readily repurposed using these technologies to support other institutions' requirements. Each individual care component and visualization was then developed and refined using extensive stakeholder engagement and an eye to the COM-B (Capability, Opportunity, and Motivation to change Behavior) principles of behavioral change, in order to promote behaviors likely to improve depression reporting, screening, comprehensive treatment and follow through.


Multiple Sclerosis, MS, Depression, Depressed, Sclerosis, Depressive Disorder, MS CATCH


You can join if…

Open to people ages 18-80

  • Diagnosis of MS (relapsing or progressive) by 2017 McDonald Criteria18
  • Ages 18 to 80
  • PHQ-9 score of 5-19
  • Any MS therapy, or no treatment
  • California resident to enable clinical telemedicine visits if warranted during the study visit

You CAN'T join if...

  • Cognitive dexterity or visual impairment (typically defined as corrected acuity less than 20/70) that, in the opinion of the study neurologist (RB), would put the participant at risk or limit their ability to adhere to the study protocol
  • Inability to provide informed consent
  • Psychotic disorders: bipolar disorder, schizophrenia, schizoaffective disorder
  • Substance abuse that in the treating neurologist's perspective could influence the patient's safety on study or adherence to study protocol
  • Another co-morbid CNS diagnosis eg. TBI


  • Weill Institute for Neurosciences, UCSF accepting new patients
    San Francisco California 94158 United States

Lead Scientist at UCSF

  • Riley Bove, MD
    Dr. Riley Bove is a practicing neurologist and clinician scientist in the UCSF Weill Institute for Neurosciences. Dr. Bove is a national and international leader in sex and gender aspects of Neurology, publishing, collaborating and lecturing widely on this topic.


accepting new patients
Start Date
Completion Date
University of California, San Francisco
Study Type
Expecting 100 study participants
Last Updated