Summary

Eligibility
for people ages 18 years and up (full criteria)
Location
at San Francisco, California
Dates
study started
estimated completion
Principal Investigator
Kimberly S Kirkwood, MDPaige M Bracci, PhD, MPH, MS
Photo of Kimberly S Kirkwood
Kimberly S Kirkwood

Description

Summary

Pancreatic cysts are found incidentally on 15-50% of CT and MRIs for all indications and their prevalence is increasing. Many of these cysts may be precursors to pancreatic cancer, and thus pose a substantial risk, however, the vast majority are benign. Increased detection of pancreatic cysts provides an opportunity to diagnose pancreatic malignancy at an early, curable stage yet also increases the potential to over-treat clinically insignificant lesions. This presents a clinical challenge to prevent unnecessary resection of indolent disease, with associated risks of infections, bleeding, diabetes, and costly disability. Unfortunately, there is little information on the epidemiology and natural history of pancreatic cysts to help guide management. This study develops a large, prospectively managed, electronic, patient-directed pancreatic cyst registry based at UCSF using the NIH-funded Eureka Health platform. PANC Cyst will facilitate work to improve clinical care and understanding of pancreatic cysts by prospective follow-up of patients with cystic lesions, especially the diagnostically challenging small cysts, to identify factors related to cyst formation and progression to malignancy. Longitudinal data capture that includes clinical outcomes will also enable us to more precisely define anatomic, radiographic and biomarker information that can be used to differentiate populations of patients for whom surgery is indicated, surveillance is warranted, or no further evaluation is necessary.

Official Title

Population-Based Analysis of Neoplastic Changes in Cystic Lesions of the Pancreas.

Keywords

Pancreatic Cyst Pancreatic Neoplasms Pancreatic Cancer Pancreatic Diseases Pancreatic IPMN IPMN Pancreatic Ductal Adenocarcinoma Mucinous Cyst Pancreatic Cystic Lesion Intraductal Papillary Mucinous Neoplasm Serous Cystadenoma Mucinous Cystic Neoplasm Cancer Epidemiology Early Detection Research Adenocarcinoma Cysts Pancreatic Intraductal Neoplasms Neoplasms Retrospective Prospective

Eligibility

You can join if…

Open to people ages 18 years and up

  • The inclusion criteria for this study are intentionally broad. Eligible patients for prospective enrollment will include
  • Adults ≥ 30 years of age
  • Have a radiographic or endoscopic diagnosis of at least one pancreatic cysts regardless of treatment status,
  • No history of pancreatic cancer,
  • Can speak and read English,
  • Have access to a computer or mobile device (~95% of U.S. population); and
  • Are able to complete an electronic informed consent.

You CAN'T join if...

  • Patients who don't speak English,
  • Don't have access to a computer or mobile device; or
  • Patients who have a cancer diagnosis.

Location

  • UCSF Medical Center accepting new patients
    San Francisco California 94158 United States

Lead Scientists at UCSF

  • Kimberly S Kirkwood, MD
    Professor, Surgery. Authored (or co-authored) 43 research publications.
  • Paige M Bracci, PhD, MPH, MS
    Professor, Epidemiology & Biostatistics. Authored (or co-authored) 203 research publications. Research interests: molecular epidemiology · cancer immunology · microbiome · pancreatic cancer · NHL · modifiable factors.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04291651
Study Type
Observational [Patient Registry]
Last Updated