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for people ages up to 25 years (full criteria)
at Oakland, California and other locations
study started



This research trial studies the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and on-going care.

Official Title

The Project: Every Child Protocol: A Registry, Eligibility Screening, Biology and Outcome Study



  1. To maintain a Childhood Cancer Registry for infants, children, adolescents, and young adults with cancer.

II. To utilize clinical and biological data to help determine eligibility or stratification, based on childhood cancer disease classification schemas, for potential enrollment of research subjects onto Children's Oncology Group (COG) therapeutic clinical trials.

III. To develop a well annotated childhood cancer biobank for current and future research through the collection of biospecimens (at diagnosis, time of progression, time of recurrence and/or post-mortem), including tumor, host and when feasible parental germline deoxyribonucleic acid (DNA); and key clinical data, including presentation, diagnostic, staging, summary treatment, and outcome information, from every child diagnosed with cancer at COG institutions.

IV. To allow use of registry data for permission to be contacted in the future to consider participating in non-therapeutic and prevention research studies involving the child or their parents.


Patients undergo medical data review to create a Childhood Cancer Registry. Patients also undergo collection of bio-specimen samples (e.g., tissue, blood, bone marrow, plasma, serum, buccal cells, saliva, cerebrospinal fluid, or urine).


Central Nervous System Neoplasm Childhood Lymphoma Childhood Relapsed Solid Tumor Nervous System Neoplasms Central Nervous System Neoplasms


For people ages up to 25 years

Inclusion Criteria:

  • Enrollment can occur at any time after disease presentation including at time of disease progression or recurrence; for patients who are to be enrolled on COG therapeutic studies, enrollment on APEC14B1 must occur prior to enrollment onto the therapeutic trial
  • Patients with a known or suspected neoplasm that occurs in the pediatric, adolescent or young adult populations are eligible for enrollment as follows:
  • All cancer cases with an International Classification of Diseases for Oncology(ICD-O) histologic behavior code of two "2" (carcinoma in situ) or three "3"(malignant)
  • All neoplastic lesions of the central nervous system regardless of behavior,i.e., benign, borderline or malignant
  • Other benign/borderline conditions including:
  • Mesoblastic nephroma
  • Teratomas
  • Myeloproliferative diseases including transient myeloproliferative disease
  • Langerhan cell histiocytosis
  • Lymphoproliferative diseases
  • Subjects must be =< 25 years of age at time of original diagnosis, except for patients who are being screened specifically for eligibility onto a COG (or COG participating National Clinical Trials Network (NCTN) ) therapeutic study, for whom there is a higher upper age limit
  • All patients or their parents or legally authorized representatives must sign a written informed consent; parents will be asked to sign a separate consent for their own biospecimen submission


  • Children's Hospital and Research Center at Oakland
    Oakland, California, 94609-1809, United States
  • UCSF Medical Center-Mission Bay
    San Francisco, California, 94158, United States
  • Kaiser Permanente-Oakland
    Oakland, California, 94611, United States
  • Children's Hospital Central California
    Madera, California, 93636-8762, United States
  • Lucile Packard Children's Hospital Stanford University
    Palo Alto, California, 94304, United States
  • University of California Davis Comprehensive Cancer Center
    Sacramento, California, 95817, United States
  • Sutter Medical Center Sacramento
    Sacramento, California, 95816, United States
  • Santa Barbara Cottage Hospital
    Santa Barbara, California, 93102, United States
  • Children's Hospital Los Angeles
    Los Angeles, California, 90027, United States
  • Mattel Children's Hospital UCLA
    Los Angeles, California, 90095, United States
  • Cedars Sinai Medical Center
    Los Angeles, California, 90048, United States
  • City of Hope Comprehensive Cancer Center
    Duarte, California, 91010, United States
  • Southern California Permanente Medical Group
    Downey, California, 90242, United States
  • Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
    Torrance, California, 90502, United States
  • Miller Children's and Women's Hospital Long Beach
    Long Beach, California, 90806, United States
  • Children's Hospital of Orange County
    Orange, California, 92868, United States
  • Loma Linda University Medical Center
    Loma Linda, California, 92354, United States
  • Summerlin Hospital Medical Center
    Las Vegas, Nevada, 89144, United States
  • University Medical Center of Southern Nevada
    Las Vegas, Nevada, 89102, United States
  • Children's Specialty Center of Nevada II
    Las Vegas, Nevada, 89109, United States
  • Sunrise Hospital and Medical Center
    Las Vegas, Nevada, 89109, United States


in progress, not accepting new patients
Start Date
Children's Oncology Group
Study Type
Last Updated
December 11, 2017