Determining Normal Range for Free Light Chains in Serum Among Twins

a study on Multiple Myeloma

Summary

Eligibility
for people ages 18-80 (full criteria)
Healthy Volunteers
healthy people welcome
Location
at San Francisco, California
Dates
study started
estimated completion
Principal Investigator
by Alan Wu
Headshot of Alan Wu
Alan Wu

Description

Summary

The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.

Official Title

Normal Range Study for Free Light Chains in Blood Among Identical or Fraternal Twins

Details

Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.

Keywords

Multiple Myeloma, free light chains, healthy twins

Eligibility

You can join if…

Open to people ages 18-80

  • Healthy subjects 18-80 years.
  • Must be an identical or fraternal twin (both must be recruited)

You CAN'T join if...

- Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -

Location

  • San Francisco General Hospital accepting new patients
    San Francisco California 94306 United States

Lead Scientist at UCSF

  • Alan Wu
    Alan Wu has several areas of expertise. He is chief of the clinical chemistry and toxicology laboratories at San Francisco General Hospital. In this capacity, his clinical and research laboratory conducts testing for routine analytes in blood, urine and cerebral spinal fluid for electrolytes, metabolites, hormones, proteins, and biomarkers.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04191057
Study Type
Interventional
Participants
Expecting 100 study participants
Last Updated
Contact us about this trial