COVID-19 clinical trials at UCSF
25 in progress, 10 open to eligible people
Coronavirus Disease 2019 (Covid-19) Impact on Alcohol-related Liver Disease Patient Outcomes, Care and Alcohol Use
open to eligible people ages 18 years and up
The study consists of a randomized controlled trial evaluating the efficacy and feasibility of a stepped alcohol treatment using telemedicine on unhealthy alcohol use in patients with chronic liver disease receiving care in hepatology practices at…
San Francisco, California and other locations
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients
open to eligible people ages 18 years and up
The goal of this project is to rapidly screen promising agents, in the setting of an adaptive platform trial, for treatment of critically ill COVID-19 patients. In this phase 2 platform design, agents will be identified with a signal suggesting a…
San Francisco, California and other locations
Imaging Immune Activation in COVID-19
open to eligible people ages 18 years and up
This is a single center, single arm exploratory imaging study involving up to two intravenous microdoses of [18F]F-AraG (the second tracer dose is optional) followed by whole-body PET-CT imaging in participants with convalescent COVID-19. Up to 80…
San Francisco, California
RECOVER-SLEEP: Platform Protocol
open to eligible people ages 18 years and up
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple interventions and…
San Francisco, California and other locations
Strategies and Treatments for Respiratory Infections & Viral Emergencies (STRIVE): Shionogi Protease Inhibitor (Ensitrelvir)
open to eligible people ages 18 years and up
Treatments are needed to improve outcomes among patients hospitalized for COVID-19, including direct-acting antiviral (DAA) agents to mitigate the pathology driven by ongoing viral replication. This trial will evaluate S-217622 (ensitrelvir), an…
Fresno, California and other locations
Strategies and Treatments for Respiratory Infections &Amp; Viral Emergencies (STRIVE): Immune Modulation Strategy Trial
open to eligible people ages 18 years and up
COVID-19 can trigger a dysregulated immune response, and previous studies have shown that immune modulation can improve outcomes in hospitalized patients. This trial is designed to determine whether intensification of immune modulation early in the…
Fresno, California and other locations
Immunologic Response Following COVID-19 Vaccination in Children, Adolescents, and Young Adults With Cancer
open to eligible people ages 6 months to 37 years
This study evaluates immunologic response following COVID-19 vaccination in children, adolescents, and young adults with cancer. Vaccines work by stimulating the body's immune cells to respond against a specific disease. The immune response produces …
Oakland, California and other locations
KIDney Injury in Times of COVID-19 (KIDCOV)
open to eligible people ages 18 years and up
There is an unmet need to evaluate the impact of sub-clinical/mild COVID19 disease in the outpatient setting on prevalent and incident renal injury, as this data is currently unavailable. To capture the diversity of race/ethnic risk and COVID19…
San Francisco, California and other locations
Long-term Impact of Infection With Novel Coronavirus (COVID-19)
open to eligible people ages 18-100
LIINC is a study of volunteers who were previously infected with SARS-CoV-2 (also known as novel coronavirus or COVID-19) who have recovered from acute infection. The study is designed to provide a specimen bank of samples with carefully…
San Francisco, California
Neural and Cognitive Consequences of COVID-19 Survival
open to eligible people ages 18-70
The novel coronavirus SARS-CoV-2 infection, COVID, continues to rage throughout the world with 115,000,000 confirmed cases and over 2,500,000 deaths (as of Mar 3, 2021). This translates to millions of people surviving COVID19 infection. While the…
San Francisco, California
EB05 + SOC Vs. Placebo + SOC in Adult Hospitalized Patients with COVID-19
Sorry, currently not accepting new patients, but might later
COVID-19 patients who develop severe disease often develop acute respiratory distress syndrome (ARDS) as a result of a dysregulated immune response. This in turn stimulates a pro-inflammatory cascade ("cytokine storm") as well as emergency…
Fresno, California and other locations
T Follicular Helper (TFH)-Targeting Genetic Vaccine Strategy Designed to Induce Broad, Durable Immune Responses
Sorry, not yet accepting patients
The goal of this clinical trial is to test two investigational COVID-19 booster vaccines, called CoTend-s3BXBB and CoTend-BXBB, in healthy volunteers ages 40-64. The CoTend-s3BXBB vaccine includes a component called "s3", which was designed to…
Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)
Sorry, in progress, not accepting new patients
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be able to be targeted by SARS-CoV-2 monoclonal…
San Francisco, California
COVID Protection After Transplant - Sanofi GSK (CPAT-SG) Study
Sorry, in progress, not accepting new patients
An open label, non-randomized pilot study in kidney transplant recipients who received a completed primary series and bivalent booster of mRNA based COVID-19 vaccine and have =<2500 U/mL SARS-CoV-2 S antibody concentration using the Roche Elecsys(R) …
San Francisco, California and other locations
Ensitrelvir for Viral Persistence and Inflammation in People Experiencing Long COVID
Sorry, in progress, not accepting new patients
Persistent viral infection with viral reservoirs and detection of circulating spike protein after the initial acute illness is one potential pathogenic mechanism for Long COVID. This mechanism may be susceptible to antiviral therapy that blocks…
San Francisco, California
Getting Asian Americans INFORMED to Facilitate COVID-19 Testing and Vaccination
Sorry, in progress, not accepting new patients
This study develops and evaluates the "INdividual and Family-Oriented Responsive Messaging EDucation" (INFORMED) intervention in increasing knowledge about COVID-19 testing and decreasing decisional conflicts of getting tested for COVID-19. A 2-arm…
San Francisco, California and other locations
RECOVER-VITAL: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms
Sorry, in progress, not accepting new patients
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent treatment plans. This …
San Francisco, California and other locations
Provide at Home Subcutaneous Administration of Pertuzumab and Trastuzumab Fixed-Dose Combination (PH FDC SC) for Patients With HER2-Positive Breast Cancer During the COVID-19 Pandemic
Sorry, not accepting new patients
This single arm, multicenter study provides the pertuzumab and trastuzumab fixed-dose combination formulation for subcutaneous injection (PH FDC SC) administered at home by a home health nursing provider for patients with human epidermal growth…
San Francisco, California and other locations
ASCO Survey on COVID-19 in Oncology (ASCO) Registry
Sorry, in progress, not accepting new patients
The American Society of Clinical Oncology (ASCO) Survey on Coronavirus 2019 (COVID-19) in Oncology Registry (ASCO Registry) aims to help the cancer community learn more about the patterns of symptoms and severity of COVID-19 among patients with…
San Francisco, California and other locations
Pregnancy In the CoRonavirus (COVID-19) pandEmic
Sorry, in progress, not accepting new patients
Prospective nationwide cohort study of pregnant women enrolled early in gestation and followed for Covid-19 exposure and infection, with follow up of obstetrical outcomes and infant development through the first year of life.
San Francisco, California
Treatment Protocol: Remdesivir (RDV; GS-5734) for the Treatment of SARS-CoV2 (CoV) Infection (COVID-19)
Sorry, not accepting new patients
The primary objective of this study is to provide expanded access of remdesivir (RDV) for the treatment of severe acute respiratory syndrome coronavirus (SARS-CoV2) infection.
San Francisco, California and other locations
Innovative Support for Patients with SARS-COV2 Infections (COVID-19) Registry (INSPIRE)
Sorry, in progress, not accepting new patients
The Innovative Support for Patients with SARS COV-2 Infections Registry (INSPIRE) study is a CDC-funded COVID-19 project to understand the long-term health outcomes in recently tested adults, both negative and positive, who have suspected COVID…
San Francisco, California and other locations
NCI COVID-19 in Cancer Patients, NCCAPS Study
Sorry, in progress, not accepting new patients
This study collects blood samples, medical information, and medical images from patients who are being treated for cancer and have a positive test for SARS CoV-2, the new coronavirus that causes the disease called COVID-19. Collecting blood samples, …
San Francisco, California and other locations
Long-term Impact of COVID on Children and Families
Sorry, in progress, not accepting new patients
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals age 0-25 years who will enter the cohort with and without SARS-CoV-2 infection at varying stages before and after infection. Individuals with…
San Francisco, California and other locations
Long-term Impact of COVID-19 in Adults (RECOVER)
Sorry, in progress, not accepting new patients
This is a combined retrospective and prospective, longitudinal, observational meta-cohort of individuals who will enter the cohort with and without SARS-CoV-2 infection and at varying stages before and after infection. Individuals with and without…
San Francisco, California and other locations
Our lead scientists for COVID-19 research studies include Jennifer G. Michlitsch Steven Deeks, MD Laura Esserman, MD Michael J Peluso, MD Janice Y Tsoh, PhD Timothy Henrich, MD Judith M Ford, PhD Heather Huddleston, MD Aric Prather Mandana Khalili, M.D. Kathleen D Liu, MD Minnie Sarwal, M.D., Ph.D..
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