Summary

Eligibility
for people ages 18-67 (full criteria)
Location
at San Francisco, California
Dates
study started
estimated completion
Principal Investigator
Steven Deeks
Photo of Steven Deeks
Steven Deeks

Description

Summary

Combination approaches will almost certainly be required to generate durable control of HIV in the absence of antiretroviral therapy (a "remission"). In this study, 20 individuals will receive a combination regimen administered during ART and then undergo an analytic treatment interruption (ATI).

Official Title

Combinatorial Therapy With a Therapeutic Conserved Element DNA Vaccine, MVA Vaccine Boost, TLR9 Agonist and Broadly Neutralizing Antibodies: a Proof-of-concept Study Aimed at Inducing an HIV Remission

Details

The investigators will perform a single arm study of twenty individuals with HIV infection on effective ART. All participants will receive a combination regimen administered during ART and then undergo an analytic treatment interruption. Our strategy has five stages

  1. IL-12 adjuvanted p24CE DNA prime (p24CE/IL-12) at Weeks 0 and 4
  2. IL-12 adjuvanted DNA boost (p24CE plus p55gag) at Week 12
  3. MVA/HIV62B (MVA62B) boost at Week 20
  4. single dose of two bNAbs (VRC07-523LS and 10-1074, which target CD4 binding site and V3 loop, respectively) at week 24 with a TLR9 agonist (lefitolimod) administered weekly between Weeks 24 and 33 (10 doses)
  5. ATI with single dose of VRC07 and 10-1074 at Week 34

Follow-up off ART will occur through at least Week 46 (expected) and on or off ART (depending on outcome) through Week 86.

Should this approach work, viral load would be expected to rebound in all individuals a few weeks after the bNAb levels decrease to sub-therapeutic levels. This acute rebound would be followed by a new lower viral load set-point and perhaps a long-term remission.

Keywords

HIV/AIDS Acquired Immunodeficiency Syndrome HIV Infections Combination Intervention

Eligibility

You can join if…

Open to people ages 18-67

  1. Willing and able to provide written informed consent.
  2. Age ≤67 years at the time of enrollment for those who started treatment during early infection and <65 years for those who started treatment during chronic infection.
  3. Documented HIV-1 infection.
  4. On continuous antiretroviral therapy for at least 12 months without any interruptions of greater than 14 consecutive days within the last 1 year, and on a stable regimen that does not include an non-nucleoside reverse transcriptase inhibitor (NNRTI) for at least 4 weeks, without plans to modify ART during the study period.
  5. Screening plasma HIV RNA levels below the level of quantification on all available determinations in past 24 months.
  6. Screening CD4+ T-cell count ≥ 500 cells/mm3.

You CAN'T join if...

  1. Subjects receiving a non-nucleoside reverse transcriptase inhibitor
  2. Pregnant, breastfeeding, or unwilling to practice birth control during participation in the study
  3. High-level resistance to both 10-1074 and VRC-07 as defined using the PhenoSense Neutralizing Antibody Assay (Monogram Biosciences).
  4. Any history of an HIV-associated malignancy, including Kaposi's sarcoma and any type of lymphoma, or virus-associated cancers.
  5. Active or recent non-HIV-associated malignancy requiring systemic chemotherapy or surgery in the preceding 36 months or for whom such therapies are expected in the subsequent 12 months.
  6. CD4+ T cell nadir <350 cells/mm3 during the chronic phase of infection (beginning 6 months following the estimated infection date and confirmed on repeat testing).
  7. Active hepatitis B (HBV) infection defined as positive HBV surface antigen test.
  8. Active hepatitis C (HCV) infection. 10. Presence of significant abnormalities on electrocardiogram. 11. History of potential immune-mediated medical conditions. Individuals with isolated Raynaud's phenomenon or localized disease requiring topical therapy alone will not be excluded.

Location

  • Zuckerberg San Francisco General Hospital, University of California San Francisco accepting new patients
    San Francisco California 94110 United States

Lead Scientist at UCSF

  • Steven Deeks
    Steven G. Deeks, MD, is a Professor of Medicine in Residence at the University of California, San Francisco (UCSF) and a faculty member in the Division of HIV, Infectious Diseases and Global Medicine at Zuckerberg San Francisco General Hospital. Dr. Deeks has been engaged in HIV research and clinical care since 1993.

Details

Status
accepting new patients
Start Date
Completion Date
(estimated)
Sponsor
University of California, San Francisco
ID
NCT04357821
Phase
Phase 1/2
Study Type
Interventional
Last Updated